Human Gene NOX4 (uc009yvs.1) Description and Page Index
  Description: Homo sapiens NADPH oxidase 4 (NOX4), transcript variant 2, mRNA.
RefSeq Summary (NM_001143836): This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009].
Transcript (Including UTRs)
   Position: hg19 chr11:89,135,494-89,224,653 Size: 89,160 Total Exon Count: 10 Strand: -


Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:89,135,494-89,224,653)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneNetworkH-INVHGNC
LynxPubMedStanford SOURCETreefamWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): NOX4
CDC HuGE Published Literature: NOX4
Positive Disease Associations: Amyotrophic Lateral Sclerosis
Related Studies:
  1. Amyotrophic Lateral Sclerosis
    Aleksey Shatunov et al. Lancet neurology 2010, Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study., Lancet neurology. [PubMed 20801717]
    We have found strong evidence of a genetic association of two single nucleotide polymorphisms on chromosome 9 with sporadic ALS, in line with findings from previous independent GWAS of ALS and linkage studies of ALS-frontotemporal dementia. Our findings together with these earlier findings suggest that genetic variation at this locus on chromosome 9 causes sporadic ALS and familial ALS-frontotemporal dementia. Resequencing studies and then functional analysis should be done to identify the defective gene.

-  MalaCards Disease Associations
  MalaCards Gene Search: NOX4
Diseases sorted by gene-association score: pulmonary hypertension (3), pulmonary fibrosis, idiopathic (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.74 RPKM in Artery - Aorta
Total median expression: 48.85 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  HW061173 - JP 2012529430-A/48: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061174 - JP 2012529430-A/49: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JA482133 - Sequence 116 from Patent WO2011072091.
JA482134 - Sequence 117 from Patent WO2011072091.
JB251981 - Sequence 48 from Patent EP2440214.
JB251982 - Sequence 49 from Patent EP2440214.
JE980425 - Sequence 116 from Patent EP2862929.
JE980426 - Sequence 117 from Patent EP2862929.
LP764880 - Sequence 48 from Patent EP3276004.
LP764881 - Sequence 49 from Patent EP3276004.
HW061175 - JP 2012529430-A/50: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JA482135 - Sequence 118 from Patent WO2011072091.
JB251983 - Sequence 50 from Patent EP2440214.
JE980427 - Sequence 118 from Patent EP2862929.
LP764882 - Sequence 50 from Patent EP3276004.
AK291830 - Homo sapiens cDNA FLJ77156 complete cds, highly similar to Homo sapiens NADPH oxidase 4 variant (NOX4) mRNA.
BC034780 - Homo sapiens mRNA similar to NADPH oxidase 4 (cDNA clone IMAGE:5179443).
AB041035 - Homo sapiens Kox-1 mRNA for kidney superoxide-producing NADPH oxidase, complete cds.
AF254621 - Homo sapiens NADPH oxidase 4 mRNA, complete cds.
AK298323 - Homo sapiens cDNA FLJ56218 complete cds, highly similar to NADPH oxidase 4 (EC 1.6.3.-).
AK057189 - Homo sapiens cDNA FLJ32627 fis, clone SYNOV1000049, highly similar to NADPH oxidase 4 (EC 1.6.3.-).
AK298376 - Homo sapiens cDNA FLJ51029 complete cds, highly similar to NADPH oxidase 4 (EC 1.6.3.-).
BC040105 - Homo sapiens NADPH oxidase 4, mRNA (cDNA clone MGC:48663 IMAGE:5590269), complete cds.
AK298357 - Homo sapiens cDNA FLJ51027 complete cds, highly similar to NADPH oxidase 4 (EC 1.6.3.-).
AK298328 - Homo sapiens cDNA FLJ51025 complete cds, highly similar to NADPH oxidase 4 (EC 1.6.3.-).
AF261943 - Homo sapiens renal NAD(P)H-oxidase renox mRNA, complete cds.
AJ704725 - Homo sapiens mRNA for NADPH oxidase 4 (NOX4 gene), splice variant A.
AJ704726 - Homo sapiens mRNA for NADPH oxidase 4 (NOX4 gene), splice variant B.
AJ704727 - Homo sapiens mRNA for NADPH oxidase 4 (NOX4 gene), splice variant C.
AJ704728 - Homo sapiens mRNA for NADPH oxidase 4 (NOX4 gene), splice variant D.
AJ704729 - Homo sapiens mRNA for NADPH oxidase 4 (NOX4 gene), splice variant E.
AY288918 - Homo sapiens NADPH oxidase 4 variant (NOX4) mRNA, complete cds.
JF432404 - Synthetic construct Homo sapiens clone IMAGE:100073606 NADPH oxidase 4 (NOX4) gene, encodes complete protein.
KJ893751 - Synthetic construct Homo sapiens clone ccsbBroadEn_03145 NOX4 gene, encodes complete protein.
AK311381 - Homo sapiens cDNA, FLJ18423.
AK311389 - Homo sapiens cDNA, FLJ18431.
CU691812 - Synthetic construct Homo sapiens gateway clone IMAGE:100021174 5' read NOX4 mRNA.
BC051371 - Homo sapiens NADPH oxidase 4, mRNA (cDNA clone IMAGE:6580820), complete cds.
JD164701 - Sequence 145725 from Patent EP1572962.
JD126043 - Sequence 107067 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK311389
UCSC ID: uc009yvs.1
RefSeq Accession: NM_001143836

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: no RNA accession: AK311389.1
exon count: 10CDS single in 3' UTR: no RNA size: 964
ORF size: 0CDS single in intron: no Alignment % ID: 99.90
txCdsPredict score: 482.50frame shift in genome: no % Coverage: 100.00
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.