Human Gene PIWIL4 (uc009ywk.2) Description and Page Index
  Description: Homo sapiens piwi-like RNA-mediated gene silencing 4 (PIWIL4), mRNA.
RefSeq Summary (NM_152431): PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005708.1, AB079366.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000299001.11/ ENSP00000299001.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr11:94,278,759-94,354,587 Size: 75,829 Total Exon Count: 19 Strand: +


Page IndexSequence and LinksGenetic AssociationsCTDRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:94,278,759-94,354,587)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblExonPrimerGeneNetworkH-INV
HGNCLynxPubMedStanford SOURCE

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PIWIL4
CDC HuGE Published Literature: PIWIL4
Positive Disease Associations: Attention Deficit Disorder with Hyperactivity , Attention deficit hyperactivity disorder symptoms (interaction)
Related Studies:
  1. Attention Deficit Disorder with Hyperactivity
    Edmund J S Sonuga-Barke et al. American journal of medical genetics. Part B, Neuropsychiatric genetics 2008, Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetic. [PubMed 18846501]
  2. Attention deficit hyperactivity disorder symptoms (interaction)
    Sonuga-Barke ,et al. 2008, Does parental expressed emotion moderate genetic effects in ADHD? an exploration using a genome wide association scan, American journal of medical genetics. Part B, Neuropsychiatric genetics 2008 147B- 8 : 1359-68. [PubMed 18846501]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.72 RPKM in Testis
Total median expression: 82.50 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  KJ900212 - Synthetic construct Homo sapiens clone ccsbBroadEn_09606 PIWIL4 gene, encodes complete protein.
AK293616 - Homo sapiens cDNA FLJ57260 complete cds, highly similar to Piwi-like protein 4.
M58597 - Human ELAM-1 ligand fucosyltransferase (ELFT) mRNA, complete cds.
BC136373 - Homo sapiens fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific), mRNA (cDNA clone MGC:167983 IMAGE:9020360), complete cds.
BC136374 - Homo sapiens fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific), mRNA (cDNA clone MGC:167984 IMAGE:9020361), complete cds.
A23701 - H.sapiens alpha(1-3)fucosyltransferase.
M58596 - Human ELAM-1 ligand fucosyltransferase (ELFT) mRNA, complete cds.
CR749642 - Homo sapiens mRNA; cDNA DKFZp686P01248 (from clone DKFZp686P01248).
JD432290 - Sequence 413314 from Patent EP1572962.
AF305083 - Homo sapiens alpha(1,3)-fucosyltransferase IV (FUTIV) gene, 3' UTR.
JD481289 - Sequence 462313 from Patent EP1572962.
JD471866 - Sequence 452890 from Patent EP1572962.
HM005708 - Homo sapiens clone HTL-T-85P testis tissue sperm-binding protein Li 85P mRNA, complete cds.
AB079366 - Homo sapiens PIWIL1 mRNA, complete cds.
AK093475 - Homo sapiens cDNA FLJ36156 fis, clone TESTI2025546, weakly similar to Mus musculus mRNA for MIWI (piwi).
AX748151 - Sequence 1676 from Patent EP1308459.
DQ891240 - Synthetic construct clone IMAGE:100003870; FLH170455.01X; RZPDo839F0798D piwi-like 4 (Drosophila) (PIWIL4) gene, encodes complete protein.
DQ894425 - Synthetic construct Homo sapiens clone IMAGE:100008885; FLH170451.01L; RZPDo839F0797D piwi-like 4 (Drosophila) (PIWIL4) gene, encodes complete protein.
BC031060 - Homo sapiens piwi-like 4 (Drosophila), mRNA (cDNA clone MGC:33296 IMAGE:5271278), complete cds.
CU689100 - Synthetic construct Homo sapiens gateway clone IMAGE:100020499 5' read PIWIL4 mRNA.
AB590313 - Synthetic construct DNA, clone: pFN21AE2266, Homo sapiens PIWIL4 gene for piwi-like 4, without stop codon, in Flexi system.
AK096837 - Homo sapiens cDNA FLJ39518 fis, clone PUAEN2001188, moderately similar to Mus musculus mRNA for MIWI (piwi).
AF086344 - Homo sapiens full length insert cDNA clone ZD61F11.
JD045213 - Sequence 26237 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04320 - Dorso-ventral axis formation

-  Other Names for This Gene
  Alternate Gene Symbols: CR749642
UCSC ID: uc009ywk.2
RefSeq Accession: NM_152431

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: CR749642.1
exon count: 19CDS single in 3' UTR: no RNA size: 3470
ORF size: 0CDS single in intron: no Alignment % ID: 99.94
txCdsPredict score: 2650.00frame shift in genome: no % Coverage: 99.48
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.