Human Gene CALM1 (uc010atq.2) Description and Page Index
Description: Homo sapiens calmodulin 1 (phosphorylase kinase, delta) (CALM1), mRNA. RefSeq Summary (NM_005184): This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]. Transcript (Including UTRs) Position: hg19 chr14:90,863,327-90,874,619 Size: 11,293 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr14:90,865,426-90,871,061 Size: 5,636 Coding Exon Count: 6
osteoarthritis Mototani, H. et al. 2005, A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese., Human molecular genetics. 2005 Apr;14(8):1009-17.
These results suggest that the transcriptional level of CALM1 is associated with susceptibility for hip OA through modulation of chondrogenic activity. Our findings reveal the CALM1-mediated signaling pathway in chondrocytes as a novel potential target for treatment of OA.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on E7ETZ0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005509 calcium ion binding
Descriptions from all associated GenBank mRNAs
JC051453 - Sequence 5 from Patent WO2013153214. JC051457 - Sequence 9 from Patent WO2013153214. JC051460 - Sequence 12 from Patent WO2013153214. BC011834 - Homo sapiens calmodulin 1 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:20018 IMAGE:3942245), complete cds. BC047523 - Homo sapiens calmodulin 1 (phosphorylase kinase, delta), mRNA (cDNA clone IMAGE:4819353). AH005375 - Homo sapiens Human calmodulin-I (CALM1) mRNA, 5'UTR, partial sequence. BC000454 - Homo sapiens calmodulin 1 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:8460 IMAGE:2821489), complete cds. BC008597 - Homo sapiens calmodulin 1 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:17489 IMAGE:3452971), complete cds. AK289937 - Homo sapiens cDNA FLJ75174 complete cds, highly similar to Homo sapiens calmodulin 1 (phosphorylase kinase, delta), mRNA. M27319 - Human calmodulin mRNA, complete cds. L37715 - Homo sapiens (clone 22) macronuclear mRNA. JD187146 - Sequence 168170 from Patent EP1572962. JD466811 - Sequence 447835 from Patent EP1572962. AY189287 - Homo sapiens LP7057 protein mRNA, complete cds. BC007965 - Homo sapiens calmodulin 1 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:14464 IMAGE:4308380), complete cds. BT006818 - Homo sapiens calmodulin 1 (phosphorylase kinase, delta) mRNA, complete cds. KJ896533 - Synthetic construct Homo sapiens clone ccsbBroadEn_05927 CALM1 gene, encodes complete protein. KJ905153 - Synthetic construct Homo sapiens clone ccsbBroadEn_14558 CALM1 gene, encodes complete protein. KJ904427 - Synthetic construct Homo sapiens clone ccsbBroadEn_13821 CALM1 gene, encodes complete protein. JD097116 - Sequence 78140 from Patent EP1572962. BX537677 - Homo sapiens mRNA; cDNA DKFZp686K05204 (from clone DKFZp686K05204). DL491437 - Novel nucleic acids. DL490058 - Novel nucleic acids. JD360025 - Sequence 341049 from Patent EP1572962. JD341250 - Sequence 322274 from Patent EP1572962. BX648223 - Homo sapiens mRNA; cDNA DKFZp779O0624 (from clone DKFZp779O0624). JD566375 - Sequence 547399 from Patent EP1572962. JD042486 - Sequence 23510 from Patent EP1572962. JD352155 - Sequence 333179 from Patent EP1572962. JD469806 - Sequence 450830 from Patent EP1572962. JD044779 - Sequence 25803 from Patent EP1572962. JD496726 - Sequence 477750 from Patent EP1572962. JD231650 - Sequence 212674 from Patent EP1572962. JD528541 - Sequence 509565 from Patent EP1572962. JD236021 - Sequence 217045 from Patent EP1572962. JD521599 - Sequence 502623 from Patent EP1572962. JD379074 - Sequence 360098 from Patent EP1572962. JD499261 - Sequence 480285 from Patent EP1572962. JD190122 - Sequence 171146 from Patent EP1572962. JD382631 - Sequence 363655 from Patent EP1572962. JD231440 - Sequence 212464 from Patent EP1572962. JD492420 - Sequence 473444 from Patent EP1572962. JD204696 - Sequence 185720 from Patent EP1572962. JD227408 - Sequence 208432 from Patent EP1572962. JD038832 - Sequence 19856 from Patent EP1572962. JD235715 - Sequence 216739 from Patent EP1572962. JD245259 - Sequence 226283 from Patent EP1572962. JD038095 - Sequence 19119 from Patent EP1572962. JD193728 - Sequence 174752 from Patent EP1572962. JD243808 - Sequence 224832 from Patent EP1572962. JD328281 - Sequence 309305 from Patent EP1572962. JD434418 - Sequence 415442 from Patent EP1572962. JD126366 - Sequence 107390 from Patent EP1572962. JD109870 - Sequence 90894 from Patent EP1572962. JD264245 - Sequence 245269 from Patent EP1572962. JD082393 - Sequence 63417 from Patent EP1572962. BC042831 - Homo sapiens calmodulin 1 (phosphorylase kinase, delta), mRNA (cDNA clone IMAGE:5301034). JD201994 - Sequence 183018 from Patent EP1572962. JD026942 - Sequence 7966 from Patent EP1572962. JD029032 - Sequence 10056 from Patent EP1572962. JD374934 - Sequence 355958 from Patent EP1572962. JD279983 - Sequence 261007 from Patent EP1572962. JD495556 - Sequence 476580 from Patent EP1572962. JD494334 - Sequence 475358 from Patent EP1572962.