Human Gene CTU2 (uc010chz.3) Description and Page Index
  Description: Homo sapiens cytosolic thiouridylase subunit 2 homolog (S. pombe) (CTU2), transcript variant 1, mRNA.
RefSeq Summary (NM_001012759): This gene encodes a protein which is involved in the post-transcriptional modification of transfer RNAs (tRNAs). The encoded protein plays a role in thiolation of uridine residue present at the wobble position in a subset of tRNAs, resulting in enhanced codon reading accuracy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
Transcript (Including UTRs)
   Position: hg19 chr16:88,772,891-88,781,786 Size: 8,896 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg19 chr16:88,772,939-88,781,659 Size: 8,721 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:88,772,891-88,781,786)mRNA (may differ from genome)Protein (586 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCLynxMGIOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: H3BSW6_HUMAN
DESCRIPTION: SubName: Full=Cytoplasmic tRNA 2-thiolation protein 2;
PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine- tRNA biosynthesis.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: CTU2
Diseases sorted by gene-association score: phobia, specific (11), exotropia (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.03 RPKM in Testis
Total median expression: 258.59 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.5048-0.323 Picture PostScript Text
3' UTR -39.50127-0.311 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019407 - Thiouridylase_cyt_su2

Pfam Domains:
PF10288 - Cytoplasmic tRNA 2-thiolation protein 2

SCOP Domains:
52402 - Adenine nucleotide alpha hydrolases-like

ModBase Predicted Comparative 3D Structure on H3BSW6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000049 tRNA binding
GO:0016779 nucleotidyltransferase activity

Biological Process:
GO:0002098 tRNA wobble uridine modification
GO:0008033 tRNA processing
GO:0032447 protein urmylation
GO:0034227 tRNA thio-modification

Cellular Component:
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC121805 - Homo sapiens chromosome 16 open reading frame 84, mRNA (cDNA clone MGC:148063 IMAGE:40107956), complete cds.
BC125269 - Homo sapiens chromosome 16 open reading frame 84, mRNA (cDNA clone MGC:148064 IMAGE:40107964), complete cds.
LF384489 - JP 2014500723-A/191992: Polycomb-Associated Non-Coding RNAs.
BC157881 - Homo sapiens chromosome 16 open reading frame 84, mRNA (cDNA clone MGC:189706 IMAGE:8862703), complete cds.
AK299521 - Homo sapiens cDNA FLJ59594 complete cds.
BC108659 - Homo sapiens chromosome 16 open reading frame 84, mRNA (cDNA clone MGC:131681 IMAGE:6167465), complete cds.
BC021056 - Homo sapiens chromosome 16 open reading frame 84, mRNA (cDNA clone IMAGE:2989282).
BC063512 - Homo sapiens chromosome 16 open reading frame 84, mRNA (cDNA clone IMAGE:3877613), with apparent retained intron.
BC080540 - Homo sapiens chromosome 16 open reading frame 84, mRNA (cDNA clone IMAGE:5458809), partial cds.
BC021829 - Homo sapiens chromosome 16 open reading frame 84, mRNA (cDNA clone IMAGE:3452981), containing frame-shift errors.
BC044951 - Homo sapiens chromosome 16 open reading frame 84, mRNA (cDNA clone IMAGE:5225154), with apparent retained intron.
JD023425 - Sequence 4449 from Patent EP1572962.
JD031461 - Sequence 12485 from Patent EP1572962.
JD389519 - Sequence 370543 from Patent EP1572962.
JD051720 - Sequence 32744 from Patent EP1572962.
JD398516 - Sequence 379540 from Patent EP1572962.
JD173306 - Sequence 154330 from Patent EP1572962.
JD056670 - Sequence 37694 from Patent EP1572962.
JD497199 - Sequence 478223 from Patent EP1572962.
MA620066 - JP 2018138019-A/191992: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: BC063512, H3BSW6, H3BSW6_HUMAN, NM_001012759, NP_001012777
UCSC ID: uc010chz.3
RefSeq Accession: NM_001012759
Protein: H3BSW6

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC063512.1
exon count: 15CDS single in 3' UTR: no RNA size: 2027
ORF size: 1761CDS single in intron: no Alignment % ID: 99.79
txCdsPredict score: 2650.00frame shift in genome: no % Coverage: 93.59
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.