Human Gene HOXB3 (uc010dbf.3) Description and Page Index
Description: Homo sapiens homeobox B3 (HOXB3), mRNA. RefSeq Summary (NM_002146): This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr17:46,626,232-46,667,631 Size: 41,400 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr17:46,627,696-46,629,836 Size: 2,141 Coding Exon Count: 2
ID:HXB3_HUMAN DESCRIPTION: RecName: Full=Homeobox protein Hox-B3; AltName: Full=Homeobox protein Hox-2.7; AltName: Full=Homeobox protein Hox-2G; FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. SUBCELLULAR LOCATION: Nucleus. DEVELOPMENTAL STAGE: Expressed in whole embryos and fetuses at 5-9 weeks from conception. SIMILARITY: Belongs to the Antp homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P14651
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding