Description: Homo sapiens galanin-like peptide (GALP), transcript variant 2, mRNA. RefSeq Summary (NM_001145546): This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014]. Transcript (Including UTRs) Position: hg19 chr19:56,687,389-56,697,144 Size: 9,756 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr19:56,688,478-56,693,603 Size: 5,126 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q9UBC7-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
AF188492 - Homo sapiens clone pGR2HL14 galanin-like peptide precursor, mRNA, complete cds. AF188493 - Homo sapiens clone pGR2HL02 galanin-like peptide precursor, mRNA, complete cds. JD338814 - Sequence 319838 from Patent EP1572962. JD160499 - Sequence 141523 from Patent EP1572962. JD074568 - Sequence 55592 from Patent EP1572962. BC141468 - Synthetic construct Homo sapiens clone IMAGE:100014766, MGC:175373 galanin-like peptide (GALP) mRNA, encodes complete protein. BC148722 - Synthetic construct Homo sapiens clone IMAGE:100015707, MGC:183156 galanin-like peptide (GALP) mRNA, encodes complete protein. AY329637 - Homo sapiens alarin precursor, mRNA, complete cds, alternatively spliced. JD340009 - Sequence 321033 from Patent EP1572962. JD146873 - Sequence 127897 from Patent EP1572962. JD521645 - Sequence 502669 from Patent EP1572962. JD149542 - Sequence 130566 from Patent EP1572962. JD150477 - Sequence 131501 from Patent EP1572962. JD538396 - Sequence 519420 from Patent EP1572962.