Human Gene GALP (uc010eti.2) Description and Page Index
Description: Homo sapiens galanin-like peptide (GALP), transcript variant 2, mRNA. RefSeq Summary (NM_001145546): This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014]. Transcript (Including UTRs) Position: hg19 chr19:56,687,389-56,697,144 Size: 9,756 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr19:56,688,478-56,693,603 Size: 5,126 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q9UBC7-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
AF188492 - Homo sapiens clone pGR2HL14 galanin-like peptide precursor, mRNA, complete cds. AF188493 - Homo sapiens clone pGR2HL02 galanin-like peptide precursor, mRNA, complete cds. JD338814 - Sequence 319838 from Patent EP1572962. JD160499 - Sequence 141523 from Patent EP1572962. JD074568 - Sequence 55592 from Patent EP1572962. BC141468 - Synthetic construct Homo sapiens clone IMAGE:100014766, MGC:175373 galanin-like peptide (GALP) mRNA, encodes complete protein. BC148722 - Synthetic construct Homo sapiens clone IMAGE:100015707, MGC:183156 galanin-like peptide (GALP) mRNA, encodes complete protein. AY329637 - Homo sapiens alarin precursor, mRNA, complete cds, alternatively spliced. JD340009 - Sequence 321033 from Patent EP1572962. JD146873 - Sequence 127897 from Patent EP1572962. JD521645 - Sequence 502669 from Patent EP1572962. JD149542 - Sequence 130566 from Patent EP1572962. JD150477 - Sequence 131501 from Patent EP1572962. JD538396 - Sequence 519420 from Patent EP1572962.