Human Gene GALP (uc010eti.2) Description and Page Index
  Description: Homo sapiens galanin-like peptide (GALP), transcript variant 2, mRNA.
RefSeq Summary (NM_001145546): This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014].
Transcript (Including UTRs)
   Position: hg19 chr19:56,687,389-56,697,144 Size: 9,756 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr19:56,688,478-56,693,603 Size: 5,126 Coding Exon Count: 2 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:56,687,389-56,697,144)mRNA (may differ from genome)Protein (49 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
HGNCLynxMGIOMIMPubMedStanford SOURCE
UniProtKB

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GALP
CDC HuGE Published Literature: GALP

-  MalaCards Disease Associations
  MalaCards Gene Search: GALP
Diseases sorted by gene-association score: ganglioneuroblastoma (10), ganglioneuroma (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.11 RPKM in Testis
Total median expression: 0.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.5082-0.457 Picture PostScript Text
3' UTR -180.19657-0.274 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q9UBC7-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AF188492 - Homo sapiens clone pGR2HL14 galanin-like peptide precursor, mRNA, complete cds.
AF188493 - Homo sapiens clone pGR2HL02 galanin-like peptide precursor, mRNA, complete cds.
JD338814 - Sequence 319838 from Patent EP1572962.
JD160499 - Sequence 141523 from Patent EP1572962.
JD074568 - Sequence 55592 from Patent EP1572962.
BC141468 - Synthetic construct Homo sapiens clone IMAGE:100014766, MGC:175373 galanin-like peptide (GALP) mRNA, encodes complete protein.
BC148722 - Synthetic construct Homo sapiens clone IMAGE:100015707, MGC:183156 galanin-like peptide (GALP) mRNA, encodes complete protein.
AY329637 - Homo sapiens alarin precursor, mRNA, complete cds, alternatively spliced.
JD340009 - Sequence 321033 from Patent EP1572962.
JD146873 - Sequence 127897 from Patent EP1572962.
JD521645 - Sequence 502669 from Patent EP1572962.
JD149542 - Sequence 130566 from Patent EP1572962.
JD150477 - Sequence 131501 from Patent EP1572962.
JD538396 - Sequence 519420 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001145546, NP_001139018, Q9UBC7-2
UCSC ID: uc010eti.2
RefSeq Accession: NM_001145546
Protein: Q9UBC7-2, splice isoform of Q9UBC7 CCDS: CCDS46202.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: yes RNA accession: NM_001145546.1
exon count: 5CDS single in 3' UTR: no RNA size: 889
ORF size: 150CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 492.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.