Human Gene CDK5RAP1 (ENST00000339269.5) from GENCODE V44
Description: Homo sapiens CDK5 regulatory subunit associated protein 1 (CDK5RAP1), transcript variant 4, mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_001278168) RefSeq Summary (NM_001278168): This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]. Gencode Transcript: ENST00000339269.5 Gencode Gene: ENSG00000101391.21 Transcript (Including UTRs) Position: hg38 chr20:33,358,839-33,401,561 Size: 42,723 Total Exon Count: 13 Strand: - Coding Region Position: hg38 chr20:33,359,043-33,397,064 Size: 38,022 Coding Exon Count: 12
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04055 - Radical SAM superfamily PF01938 - TRAM domain PF00919 - Uncharacterized protein family UPF0004
ModBase Predicted Comparative 3D Structure on Q96SZ6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.