Human Gene CRHBP (ENST00000506501.1) from GENCODE V44
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt D6RHH7)
RefSeq Summary (NM_001882): Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000506501.1
Gencode Gene: ENSG00000145708.11
Transcript (Including UTRs)
   Position: hg38 chr5:76,953,049-76,959,022 Size: 5,974 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr5:76,953,135-76,958,913 Size: 5,779 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:76,953,049-76,959,022)mRNA (may differ from genome)Protein (238 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: D6RHH7_HUMAN
DESCRIPTION: SubName: Full=Corticotropin-releasing factor-binding protein;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.55 RPKM in Spleen
Total median expression: 89.70 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.3086-0.294 Picture PostScript Text
3' UTR -22.90109-0.210 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008435 - CRF-bd
IPR000859 - CUB

Pfam Domains:
PF05428 - Corticotropin-releasing factor binding protein (CRF-BP)

ModBase Predicted Comparative 3D Structure on D6RHH7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0051424 corticotropin-releasing hormone binding


-  Descriptions from all associated GenBank mRNAs
  AK223457 - Homo sapiens mRNA for corticotropin releasing hormone binding protein variant, clone: FCC115E06.
AK307729 - Homo sapiens cDNA, FLJ97677.
BC018038 - Homo sapiens corticotropin releasing hormone binding protein, mRNA (cDNA clone MGC:26246 IMAGE:4812893), complete cds.
AK311052 - Homo sapiens cDNA, FLJ18094.
JD423153 - Sequence 404177 from Patent EP1572962.
JD457093 - Sequence 438117 from Patent EP1572962.
X58022 - Human mRNA for corticotropin-releasing factor binding protein (CRF-BP).
CU676144 - Synthetic construct Homo sapiens gateway clone IMAGE:100018909 5' read CRHBP mRNA.
HQ447855 - Synthetic construct Homo sapiens clone IMAGE:100071199; CCSB001253_01 corticotropin releasing hormone binding protein (CRHBP) gene, encodes complete protein.
KJ890968 - Synthetic construct Homo sapiens clone ccsbBroadEn_00362 CRHBP gene, encodes complete protein.
CR541666 - Homo sapiens full open reading frame cDNA clone RZPDo834H0627D for gene CRHBP, corticotropin releasing hormone binding protein; complete cds, incl. stopcodon.

-  Other Names for This Gene
  Alternate Gene Symbols: AK311052, D6RHH7, D6RHH7_HUMAN, uc010izx.1, uc010izx.2, uc010izx.3, uc010izx.4
UCSC ID: ENST00000506501.1
RefSeq Accession: NM_001882
Protein: D6RHH7

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.