Human Gene CRHBP (ENST00000506501.1) from GENCODE V44
Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt D6RHH7) RefSeq Summary (NM_001882): Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000506501.1 Gencode Gene: ENSG00000145708.11 Transcript (Including UTRs) Position: hg38 chr5:76,953,049-76,959,022 Size: 5,974 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr5:76,953,135-76,958,913 Size: 5,779 Coding Exon Count: 5
ID:D6RHH7_HUMAN DESCRIPTION: SubName: Full=Corticotropin-releasing factor-binding protein; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05428 - Corticotropin-releasing factor binding protein (CRF-BP)
ModBase Predicted Comparative 3D Structure on D6RHH7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.