Human Gene PTCRA (ENST00000441198.4) from GENCODE V44
Description: Homo sapiens pre T cell antigen receptor alpha (PTCRA), transcript variant 3, mRNA. (from RefSeq NM_001243169) RefSeq Summary (NM_001243169): The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]. Gencode Transcript: ENST00000441198.4 Gencode Gene: ENSG00000171611.10 Transcript (Including UTRs) Position: hg38 chr6:42,915,989-42,925,835 Size: 9,847 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr6:42,916,070-42,925,682 Size: 9,613 Coding Exon Count: 5
ID:PTCRA_HUMAN DESCRIPTION: RecName: Full=Pre T-cell antigen receptor alpha; Short=pT-alpha; Short=pTa; AltName: Full=pT-alpha-TCR; Flags: Precursor; FUNCTION: The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development (By similarity). SUBUNIT: Heterodimer with TCRB; disulfide linked. This heterodimer assembles with CD3 proteins into a signaling-competent pre-T-cell receptor complex. Interacts with RHBDD1. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow. DEVELOPMENTAL STAGE: Expressed in fetal life in CD34+ progenitors present in the liver at 18 weeks of gestation but is absent in CD34+ precursors from fetal bone marrow at any developmental stage up to 22 weeks.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ISU1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
