Human Gene PLXNB3 (ENST00000538966.5) from GENCODE V44
Description: Homo sapiens plexin B3 (PLXNB3), transcript variant 2, mRNA. (from RefSeq NM_001163257) RefSeq Summary (NM_001163257): The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]. Gencode Transcript: ENST00000538966.5 Gencode Gene: ENSG00000198753.12 Transcript (Including UTRs) Position: hg38 chrX:153,764,196-153,779,346 Size: 15,151 Total Exon Count: 37 Strand: + Coding Region Position: hg38 chrX:153,766,211-153,779,039 Size: 12,829 Coding Exon Count: 35
ID:PLXB3_HUMAN DESCRIPTION: RecName: Full=Plexin-B3; Flags: Precursor; FUNCTION: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. SUBUNIT: Interacts (via cytoplasmic domain) with RAC1 and ARHGDIA (By similarity). Binds MET and MST1R. Interacts (via cytoplasmic domain) with FSCN1. Interacts with RIT2/RIN. May form homodimers (via Sema domain). INTERACTION: P08581:MET; NbExp=2; IntAct=EBI-311073, EBI-1039152; Q04912:MST1R; NbExp=2; IntAct=EBI-311073, EBI-2637518; SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with RIT2/RIN at the plasma membrane. TISSUE SPECIFICITY: Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines. SIMILARITY: Belongs to the plexin family. SIMILARITY: Contains 4 IPT/TIG domains. SIMILARITY: Contains 3 PSI domains. SIMILARITY: Contains 1 Sema domain. SEQUENCE CAUTION: Sequence=BAA86520.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9ULL4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
