Human Gene SIPA1 (ENST00000527525.5) from GENCODE V44
Description: Contains 1 PDZ (DHR) domain. (from UniProt F6RY50) RefSeq Summary (NM_006747): The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000527525.5 Gencode Gene: ENSG00000213445.10 Transcript (Including UTRs) Position: hg38 chr11:65,639,866-65,650,880 Size: 11,015 Total Exon Count: 17 Strand: + Coding Region Position: hg38 chr11:65,640,922-65,650,715 Size: 9,794 Coding Exon Count: 16
ID:F6RY50_HUMAN DESCRIPTION: SubName: Full=Signal-induced proliferation-associated protein 1; SIMILARITY: Contains 1 PDZ (DHR) domain. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00595 - PDZ domain (Also known as DHR or GLGF) PF02145 - Rap/ran-GAP
ModBase Predicted Comparative 3D Structure on F6RY50
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
