Human Gene PLEKHH1 (uc010tsw.1) Description and Page Index
Description: Homo sapiens pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 (PLEKHH1), mRNA.
Transcript (Including UTRs)
Position: hg19 chr14:68,035,750-68,056,255 Size: 20,506 Total Exon Count: 22 Strand: +
Position: hg19 chr14:68,035,888-68,053,952 Size: 18,065 Coding Exon Count: 22
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Pleckstrin homology domain-containing family H member 1; Short=PH domain-containing family H member 1;
SIMILARITY: Contains 1 FERM domain. SIMILARITY: Contains 1 MyTH4 domain. SIMILARITY: Contains 2 PH domains. SEQUENCE CAUTION: Sequence=BAA86514.1; Type=Erroneous initiation;
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR019749 - Band_41_domain
IPR014352 - FERM/acyl-CoA-bd_prot_3-hlx
IPR019748 - FERM_central
IPR000299 - FERM_domain
IPR000857 - MyTH4_dom
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
Pfam Domains: PF00169 - PH domain
PF00373 - FERM central domain
PF00784 - MyTH4 domain
PF14593 - PH domain
SCOP Domains: 47031 - Second domain of FERM
50729 - PH domain-like
ModBase Predicted Comparative 3D Structure on Q9ULM0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK307428 - Homo sapiens cDNA, FLJ97376. AB033026 - Homo sapiens KIAA1200 mRNA for KIAA1200 protein. BC146787 - Homo sapiens pleckstrin homology domain containing, family H (with MyTH4 domain) member 1, mRNA (cDNA clone MGC:166876 IMAGE:9007246), complete cds. AB384136 - Synthetic construct DNA, clone: pF1KSDA1200, Homo sapiens PLEKHH1 gene for pleckstrin homology domain-containing protein, family H member 1, complete cds, without stop codon, in Flexi system. AK295896 - Homo sapiens cDNA FLJ56902 complete cds, highly similar to Homo sapiens pleckstrin homology domain containing, family H member 1, mRNA. AK123305 - Homo sapiens cDNA FLJ41311 fis, clone BRAMY2042760. BX648464 - Homo sapiens mRNA; cDNA DKFZp686C0111 (from clone DKFZp686C0111). AK293950 - Homo sapiens cDNA FLJ55536 complete cds, highly similar to Homo sapiens pleckstrin homology domain containing, family H member 1, mRNA. BX648137 - Homo sapiens mRNA; cDNA DKFZp686H1246 (from clone DKFZp686H1246). AK124787 - Homo sapiens cDNA FLJ42797 fis, clone BRAWH3008697, highly similar to Homo sapiens pleckstrin homology domain containing, family H member 1, mRNA. BC014159 - Homo sapiens pleckstrin homology domain containing, family H (with MyTH4 domain) member 1, mRNA (cDNA clone IMAGE:4542621), partial cds. DQ587411 - Homo sapiens piRNA piR-54523, complete sequence. AK123262 - Homo sapiens cDNA FLJ41268 fis, clone BRAMY2036076. BC037820 - Homo sapiens cDNA clone IMAGE:4800000. JD145313 - Sequence 126337 from Patent EP1572962. JD096538 - Sequence 77562 from Patent EP1572962. JD164369 - Sequence 145393 from Patent EP1572962. JD356243 - Sequence 337267 from Patent EP1572962. JD303185 - Sequence 284209 from Patent EP1572962. JD299343 - Sequence 280367 from Patent EP1572962. JD363967 - Sequence 344991 from Patent EP1572962. JD214809 - Sequence 195833 from Patent EP1572962. JD239600 - Sequence 220624 from Patent EP1572962. JD490016 - Sequence 471040 from Patent EP1572962. JD226056 - Sequence 207080 from Patent EP1572962. JD433333 - Sequence 414357 from Patent EP1572962. JD292329 - Sequence 273353 from Patent EP1572962. JD260048 - Sequence 241072 from Patent EP1572962. JD363634 - Sequence 344658 from Patent EP1572962. JD225905 - Sequence 206929 from Patent EP1572962. JD563088 - Sequence 544112 from Patent EP1572962. JD112600 - Sequence 93624 from Patent EP1572962. JD239439 - Sequence 220463 from Patent EP1572962. JD081684 - Sequence 62708 from Patent EP1572962. JD486946 - Sequence 467970 from Patent EP1572962. JD253227 - Sequence 234251 from Patent EP1572962. JD116002 - Sequence 97026 from Patent EP1572962. JD415723 - Sequence 396747 from Patent EP1572962. JD284996 - Sequence 266020 from Patent EP1572962. JD238702 - Sequence 219726 from Patent EP1572962. JD548385 - Sequence 529409 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: A6H8X6, AK295896, KIAA1200, NM_020715, NP_065766, PKHH1_HUMAN, Q6PJL4, Q6ZWC7, Q9ULM0 UCSC ID: uc010tsw.1 RefSeq Accession: NM_020715
(aka PKHH1_HUMAN) Q9ULM0
Gene Model Information
22 CDS single in 3' UTR:
2799 CDS single in intron:
Alignment % ID:
4207.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
105 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.