Human Gene VPS33B (ENST00000535906.1) from GENCODE V44
Description: Homo sapiens VPS33B late endosome and lysosome associated (VPS33B), transcript variant 3, mRNA. (from RefSeq NM_001289149) RefSeq Summary (NM_001289148): Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Gencode Transcript: ENST00000535906.1 Gencode Gene: ENSG00000184056.15 Transcript (Including UTRs) Position: hg38 chr15:90,998,675-91,022,596 Size: 23,922 Total Exon Count: 22 Strand: - Coding Region Position: hg38 chr15:90,998,975-91,022,249 Size: 23,275 Coding Exon Count: 22
ID:F5H008_HUMAN DESCRIPTION: SubName: Full=Vacuolar protein sorting-associated protein 33B; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on F5H008
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.