Human Gene SH2B1 (ENST00000538342.5) from GENCODE V44
Description: Homo sapiens SH2B adaptor protein 1 (SH2B1), transcript variant 7, mRNA. (from RefSeq NM_001308294) RefSeq Summary (NM_001308294): This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]. Gencode Transcript: ENST00000538342.5 Gencode Gene: ENSG00000178188.16 Transcript (Including UTRs) Position: hg38 chr16:28,863,806-28,873,823 Size: 10,018 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr16:28,867,400-28,873,465 Size: 6,066 Coding Exon Count: 8
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on B4DLN5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.