Description: Homo sapiens piezo-type mechanosensitive ion channel component 1 (PIEZO1), mRNA. RefSeq Summary (NM_001142864): The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. [provided by RefSeq, Jul 2015]. Transcript (Including UTRs) Position: hg19 chr16:88,781,746-88,851,372 Size: 69,627 Total Exon Count: 51 Strand: - Coding Region Position: hg19 chr16:88,782,013-88,851,372 Size: 69,360 Coding Exon Count: 51
ID:PIEZ1_HUMAN DESCRIPTION: RecName: Full=Piezo-type mechanosensitive ion channel component 1; AltName: Full=Membrane protein induced by beta-amyloid treatment; Short=Mib; AltName: Full=Protein FAM38A; FUNCTION: Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. MISCELLANEOUS: Piezo comes from the Greek 'piesi' meaning pressure. SIMILARITY: Belongs to the PIEZO family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92508
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006812 cation transport GO:0033625 positive regulation of integrin activation GO:0033634 positive regulation of cell-cell adhesion mediated by integrin GO:0034220 ion transmembrane transport GO:0042391 regulation of membrane potential GO:0050982 detection of mechanical stimulus GO:0055085 transmembrane transport GO:0071260 cellular response to mechanical stimulus GO:0098655 cation transmembrane transport
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