Human Gene MED24 (uc010weu.2) Description and Page Index
  Description: Homo sapiens mediator complex subunit 24 (MED24), transcript variant 4, non-coding RNA.
RefSeq Summary (NR_052017): This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr17:38,175,350-38,210,889 Size: 35,540 Total Exon Count: 25 Strand: -
Coding Region
   Position: hg19 chr17:38,175,782-38,209,567 Size: 33,786 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:38,175,350-38,210,889)mRNA (may differ from genome)Protein (899 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
Stanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: F8W9R9_HUMAN
DESCRIPTION: SubName: Full=Mediator of RNA polymerase II transcription subunit 24;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: MED24
Diseases sorted by gene-association score: transposition of the great arteries (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.06 RPKM in Brain - Cerebellum
Total median expression: 819.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -156.40509-0.307 Picture PostScript Text
3' UTR -158.80432-0.368 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021429 - Mediator_Med24_N

Pfam Domains:
PF11277 - Mediator complex subunit 24 N-terminal

ModBase Predicted Comparative 3D Structure on F8W9R9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  LF209321 - JP 2014500723-A/16824: Polycomb-Associated Non-Coding RNAs.
BC011375 - Homo sapiens mediator complex subunit 24, mRNA (cDNA clone MGC:8748 IMAGE:3866038), complete cds.
AK291040 - Homo sapiens cDNA FLJ77699 complete cds.
D50920 - Homo sapiens mRNA for KIAA0130 gene.
AK300992 - Homo sapiens cDNA FLJ59441 complete cds, highly similar to Thyroid hormone receptor-associated proteincomplex 100 kDa component.
AK022508 - Homo sapiens cDNA FLJ12446 fis, clone NT2RM1000260, highly similar to Thyroid hormone receptor-associated protein complex 100 kDa component.
EU392538 - Homo sapiens mediator complex subunit MED24 variant MED24_i7 (MED24) mRNA, partial cds, alternatively spliced.
EU392543 - Homo sapiens mediator complex subunit MED24 variant MED24_i12 (MED24) mRNA, partial cds, alternatively spliced.
EU392544 - Homo sapiens mediator complex subunit MED24 variant MED24_i13 (MED24) mRNA, partial cds, alternatively spliced.
EU392554 - Homo sapiens mediator complex subunit MED24 variant MED24_i23 (MED24) mRNA, complete sequence, alternatively spliced.
EU392546 - Homo sapiens mediator complex subunit MED24 variant MED24_i15 (MED24) mRNA, complete cds, alternatively spliced.
EU392547 - Homo sapiens mediator complex subunit MED24 variant MED24_i16 (MED24) mRNA, complete cds, alternatively spliced.
EU392537 - Homo sapiens mediator complex subunit MED24 variant MED24_i6 (MED24) mRNA, partial cds, alternatively spliced.
EU392545 - Homo sapiens mediator complex subunit MED24 variant MED24_i14 (MED24) mRNA, partial cds, alternatively spliced.
EU392552 - Homo sapiens mediator complex subunit MED24 variant MED24_i21 (MED24) mRNA, complete sequence, alternatively spliced.
AK303745 - Homo sapiens cDNA FLJ59652 complete cds, highly similar to Thyroid hormone receptor-associated protein complex 100 kDa component.
JD123657 - Sequence 104681 from Patent EP1572962.
JD190715 - Sequence 171739 from Patent EP1572962.
JD194115 - Sequence 175139 from Patent EP1572962.
JD099702 - Sequence 80726 from Patent EP1572962.
JD473824 - Sequence 454848 from Patent EP1572962.
JD386276 - Sequence 367300 from Patent EP1572962.
AK299864 - Homo sapiens cDNA FLJ59414 complete cds, highly similar to Thyroid hormone receptor-associated protein complex 100 kDa component.
JD254731 - Sequence 235755 from Patent EP1572962.
JD554808 - Sequence 535832 from Patent EP1572962.
JD073429 - Sequence 54453 from Patent EP1572962.
JD342794 - Sequence 323818 from Patent EP1572962.
JD466507 - Sequence 447531 from Patent EP1572962.
AK303502 - Homo sapiens cDNA FLJ58560 complete cds, highly similar to Thyroid hormone receptor-associated protein complex 100 kDa component.
AF055995 - Homo sapiens thyroid hormone receptor-associated protein complex component TRAP100 mRNA, complete cds.
AF277379 - Homo sapiens vitamin D receptor-interacting protein complex component DRIP100 (DRIP100) mRNA, complete cds.
KJ898105 - Synthetic construct Homo sapiens clone ccsbBroadEn_07499 MED24 gene, encodes complete protein.
DQ891082 - Synthetic construct clone IMAGE:100003712; FLH169154.01X; RZPDo839H0194D thyroid hormone receptor associated protein 4 (THRAP4) gene, encodes complete protein.
DQ894264 - Synthetic construct Homo sapiens clone IMAGE:100008724; FLH169150.01L; RZPDo839H0193D thyroid hormone receptor associated protein 4 (THRAP4) gene, encodes complete protein.
AB385282 - Synthetic construct DNA, clone: pF1KA0130, Homo sapiens THRAP4 gene for thyroid hormone receptor-associated protein complex 100 kDa component, complete cds, without stop codon, in Flexi system.
EU392533 - Homo sapiens mediator complex subunit MED24 variant MED24_i2 (MED24) mRNA, partial cds, alternatively spliced.
EU392540 - Homo sapiens mediator complex subunit MED24 variant MED24_i9 (MED24) mRNA, partial cds, alternatively spliced.
EU392542 - Homo sapiens mediator complex subunit MED24 variant MED24_i11 (MED24) mRNA, partial cds, alternatively spliced.
EU392553 - Homo sapiens mediator complex subunit MED24 variant MED24_i22 (MED24) mRNA, complete sequence, alternatively spliced.
AK293309 - Homo sapiens cDNA FLJ59464 complete cds, highly similar to Thyroid hormone receptor-associated proteincomplex 100 kDa component.
LF327663 - JP 2014500723-A/135166: Polycomb-Associated Non-Coding RNAs.
EU392539 - Homo sapiens mediator complex subunit MED24 variant MED24_i8 (MED24) mRNA, partial cds, alternatively spliced.
EU392550 - Homo sapiens mediator complex subunit MED24 variant MED24_i19 (MED24) mRNA, complete sequence, alternatively spliced.
EU392551 - Homo sapiens mediator complex subunit MED24 variant MED24_i20 (MED24) mRNA, complete sequence, alternatively spliced.
EU392541 - Homo sapiens mediator complex subunit MED24 variant MED24_i10 (MED24) mRNA, partial cds, alternatively spliced.
LF327664 - JP 2014500723-A/135167: Polycomb-Associated Non-Coding RNAs.
LF327665 - JP 2014500723-A/135168: Polycomb-Associated Non-Coding RNAs.
CU679914 - Synthetic construct Homo sapiens gateway clone IMAGE:100017513 5' read MED24 mRNA.
EU392534 - Homo sapiens mediator complex subunit MED24 variant MED24_i3 (MED24) mRNA, partial cds, alternatively spliced.
EU392549 - Homo sapiens mediator complex subunit MED24 variant MED24_i18 (MED24) mRNA, complete sequence, alternatively spliced.
EU392536 - Homo sapiens mediator complex subunit MED24 variant MED24_i5 (MED24) mRNA, partial cds, alternatively spliced.
EU392535 - Homo sapiens mediator complex subunit MED24 variant MED24_i4 (MED24) mRNA, partial cds, alternatively spliced.
EU392548 - Homo sapiens mediator complex subunit MED24 variant MED24_i17 (MED24) mRNA, complete sequence, alternatively spliced.
JD466110 - Sequence 447134 from Patent EP1572962.
LF327670 - JP 2014500723-A/135173: Polycomb-Associated Non-Coding RNAs.
MA563240 - JP 2018138019-A/135166: Polycomb-Associated Non-Coding RNAs.
MA563241 - JP 2018138019-A/135167: Polycomb-Associated Non-Coding RNAs.
MA563242 - JP 2018138019-A/135168: Polycomb-Associated Non-Coding RNAs.
MA563247 - JP 2018138019-A/135173: Polycomb-Associated Non-Coding RNAs.
MA444898 - JP 2018138019-A/16824: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: F8W9R9, F8W9R9_HUMAN, NR_052017
UCSC ID: uc010weu.2
RefSeq Accession: NR_052017
Protein: F8W9R9

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NR_052017.1
exon count: 25CDS single in 3' UTR: no RNA size: 3641
ORF size: 2700CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4475.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.