Human Gene MRPL10 (uc010wky.2) Description and Page Index
  Description: Homo sapiens mitochondrial ribosomal protein L10 (MRPL10), transcript variant 3, non-coding RNA.
RefSeq Summary (NM_148887): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010].
Transcript (Including UTRs)
   Position: hg19 chr17:45,900,638-45,908,907 Size: 8,270 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr17:45,901,571-45,905,971 Size: 4,401 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:45,900,638-45,908,907)mRNA (may differ from genome)Protein (222 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCETreefam

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=39S ribosomal protein L10, mitochondrial; Short=L10mt; Short=MRP-L10; AltName: Full=39S ribosomal protein L8, mitochondrial; Short=L8mt; Short=MRP-L8; Flags: Precursor;
SUBUNIT: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity).
SUBCELLULAR LOCATION: Mitochondrion (By similarity).
SIMILARITY: Belongs to the ribosomal protein L10P family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MRPL10
CDC HuGE Published Literature: MRPL10

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.75 RPKM in Ovary
Total median expression: 852.55 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -109.90296-0.371 Picture PostScript Text
3' UTR -305.54933-0.327 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001790 - Ribosomal_L10/acidic_P0

Pfam Domains:
PF00466 - Ribosomal protein L10

ModBase Predicted Comparative 3D Structure on Q7Z7H8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGD  WormBase 
 Protein Sequence  Protein Sequence 
 Alignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding

Biological Process:
GO:0006412 translation
GO:0032543 mitochondrial translation
GO:0042254 ribosome biogenesis
GO:0070125 mitochondrial translational elongation
GO:0070126 mitochondrial translational termination

Cellular Component:
GO:0005622 intracellular
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

-  Descriptions from all associated GenBank mRNAs
  JD290413 - Sequence 271437 from Patent EP1572962.
JD286172 - Sequence 267196 from Patent EP1572962.
BC015904 - Homo sapiens mitochondrial ribosomal protein L10, mRNA (cDNA clone MGC:17973 IMAGE:3919892), complete cds.
BC052601 - Homo sapiens mitochondrial ribosomal protein L10, mRNA (cDNA clone MGC:59869 IMAGE:6085551), complete cds.
BC039852 - Homo sapiens, similar to mitochondrial ribosomal protein L10, clone IMAGE:5195400, mRNA.
AK127167 - Homo sapiens cDNA FLJ45232 fis, clone BRCAN2021718, highly similar to Homo sapiens mitochondrial ribosomal protein L10 (MRPL10), mRNA.
JD494799 - Sequence 475823 from Patent EP1572962.
JD282457 - Sequence 263481 from Patent EP1572962.
JD034377 - Sequence 15401 from Patent EP1572962.
JD019414 - Sequence 438 from Patent EP1572962.
JD032435 - Sequence 13459 from Patent EP1572962.
JD148053 - Sequence 129077 from Patent EP1572962.
AK293624 - Homo sapiens cDNA FLJ55192 complete cds, highly similar to Homo sapiens mitochondrial ribosomal protein L10 (MRPL10), mRNA.
JD436133 - Sequence 417157 from Patent EP1572962.
JD168955 - Sequence 149979 from Patent EP1572962.
JD242518 - Sequence 223542 from Patent EP1572962.
JD347959 - Sequence 328983 from Patent EP1572962.
JD068069 - Sequence 49093 from Patent EP1572962.
JD122930 - Sequence 103954 from Patent EP1572962.
JD438999 - Sequence 420023 from Patent EP1572962.
JD264217 - Sequence 245241 from Patent EP1572962.
JD424336 - Sequence 405360 from Patent EP1572962.
JD070967 - Sequence 51991 from Patent EP1572962.
JD021348 - Sequence 2372 from Patent EP1572962.
JD031217 - Sequence 12241 from Patent EP1572962.
JD040721 - Sequence 21745 from Patent EP1572962.
JD029987 - Sequence 11011 from Patent EP1572962.
JD154145 - Sequence 135169 from Patent EP1572962.
JD392829 - Sequence 373853 from Patent EP1572962.
JD197565 - Sequence 178589 from Patent EP1572962.
JD228920 - Sequence 209944 from Patent EP1572962.
JD203687 - Sequence 184711 from Patent EP1572962.
DQ594391 - Homo sapiens piRNA piR-60503, complete sequence.
JD509653 - Sequence 490677 from Patent EP1572962.
JD092951 - Sequence 73975 from Patent EP1572962.
JD419574 - Sequence 400598 from Patent EP1572962.
JD437901 - Sequence 418925 from Patent EP1572962.
KJ895401 - Synthetic construct Homo sapiens clone ccsbBroadEn_04795 MRPL10 gene, encodes complete protein.
KJ900095 - Synthetic construct Homo sapiens clone ccsbBroadEn_09489 MRPL10 gene, encodes complete protein.
DQ894318 - Synthetic construct Homo sapiens clone IMAGE:100008778; FLH169660.01L; RZPDo839E1095D mitochondrial ribosomal protein L10 (MRPL10) gene, encodes complete protein; nuclear gene for mitochondrial product.
CU677497 - Synthetic construct Homo sapiens gateway clone IMAGE:100018653 5' read MRPL10 mRNA.
DQ891139 - Synthetic construct clone IMAGE:100003769; FLH169664.01X; RZPDo839E1096D mitochondrial ribosomal protein L10 (MRPL10) gene, encodes complete protein; nuclear gene for mitochondrial product.
CU690922 - Synthetic construct Homo sapiens gateway clone IMAGE:100022432 5' read MRPL10 mRNA.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q7Z7H8 (Reactome details) participates in the following event(s):

R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA
R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits
R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA
R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation)
R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome
R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP
R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA
R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)
R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA
R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA
R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5419276 Mitochondrial translation termination
R-HSA-5368287 Mitochondrial translation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-72766 Translation
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: A6NGJ4, MRPL8, NM_148887, NP_683685, NR_037575, Q7Z7H8, Q96B80, Q96Q55, RM10_HUMAN, RPML8
UCSC ID: uc010wky.2
RefSeq Accession: NM_148887
Protein: Q7Z7H8 (aka RM10_HUMAN)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NR_037575.1
exon count: 5CDS single in 3' UTR: no RNA size: 1903
ORF size: 669CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1356.00frame shift in genome: no % Coverage: 99.74
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.