Human Gene PRPSAP1 (ENST00000324684.8) from GENCODE V44
  Description: Homo sapiens phosphoribosyl pyrophosphate synthetase associated protein 1 (PRPSAP1), transcript variant 3, mRNA. (from RefSeq NM_001366236)
Gencode Transcript: ENST00000324684.8
Gencode Gene: ENSG00000161542.17
Transcript (Including UTRs)
   Position: hg38 chr17:76,310,934-76,354,198 Size: 43,265 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg38 chr17:76,311,542-76,332,416 Size: 20,875 Coding Exon Count: 7 

Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:76,310,934-76,354,198)mRNA (may differ from genome)Protein (282 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.73 RPKM in Testis
Total median expression: 430.72 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.30221-0.237 Picture PostScript Text
3' UTR -155.00608-0.255 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005946 - Rib-P_diPkinase

ModBase Predicted Comparative 3D Structure on B4DP31
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000287 magnesium ion binding
GO:0004749 ribose phosphate diphosphokinase activity

Biological Process:
GO:0009116 nucleoside metabolic process
GO:0009165 nucleotide biosynthetic process


-  Descriptions from all associated GenBank mRNAs
  BC009012 - Homo sapiens phosphoribosyl pyrophosphate synthetase-associated protein 1, mRNA (cDNA clone MGC:17110 IMAGE:4186365), complete cds.
AK131332 - Homo sapiens cDNA FLJ16342 fis, clone TESTI2015626, highly similar to Human mRNA for phosphoribosypyrophosphate synthetase-associated protein 39.
D61391 - Homo sapiens mRNA for phosphoribosypyrophosphate synthetase-associated protein 39, complete cds.
JD183354 - Sequence 164378 from Patent EP1572962.
JD507288 - Sequence 488312 from Patent EP1572962.
JD235471 - Sequence 216495 from Patent EP1572962.
JD268072 - Sequence 249096 from Patent EP1572962.
AK298171 - Homo sapiens cDNA FLJ57408 complete cds, highly similar to Phosphoribosyl pyrophosphatesynthetase-associated protein 1.
JD488162 - Sequence 469186 from Patent EP1572962.
JD219753 - Sequence 200777 from Patent EP1572962.
JD040421 - Sequence 21445 from Patent EP1572962.
JD434318 - Sequence 415342 from Patent EP1572962.
AK312637 - Homo sapiens cDNA, FLJ93021, highly similar to Homo sapiens phosphoribosyl pyrophosphate synthetase-associated protein 1 (PRPSAP1), mRNA.
HQ448273 - Synthetic construct Homo sapiens clone IMAGE:100071676; CCSB002821_01 phosphoribosyl pyrophosphate synthetase-associated protein 1 (PRPSAP1) gene, encodes complete protein.
KJ901666 - Synthetic construct Homo sapiens clone ccsbBroadEn_11060 PRPSAP1 gene, encodes complete protein.
AK092626 - Homo sapiens cDNA FLJ35307 fis, clone PROST2009901.
CU679229 - Synthetic construct Homo sapiens gateway clone IMAGE:100017083 5' read PRPSAP1 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DP31, B4DP31_HUMAN, ENST00000324684.1, ENST00000324684.2, ENST00000324684.3, ENST00000324684.4, ENST00000324684.5, ENST00000324684.6, ENST00000324684.7, NM_001366236, uc010wtb.1, uc010wtb.2
UCSC ID: ENST00000324684.8
RefSeq Accession: NM_001366236
Protein: B4DP31 CCDS: CCDS82209.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.