Human Gene AKAIN1 (ENST00000434239.4) from GENCODE V44
  Description: Homo sapiens A-kinase anchor inhibitor 1 (AKAIN1), transcript variant 1, mRNA. (from RefSeq NM_001145194)
Gencode Transcript: ENST00000434239.4
Gencode Gene: ENSG00000231824.4
Transcript (Including UTRs)
   Position: hg38 chr18:5,142,911-5,197,257 Size: 54,347 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr18:5,145,562-5,197,053 Size: 51,492 Coding Exon Count: 2 

Page IndexSequence and LinksPrimersRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:5,142,911-5,197,257)mRNA (may differ from genome)Protein (69 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHPRD
LynxMalacardsMGIneXtProtOMIMPubMed
UniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.31 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 51.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -96.60204-0.474 Picture PostScript Text
3' UTR -670.602651-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019511 - Kinase-A_anchor_RI-RII-bd_dom

Pfam Domains:
PF10470 - PKA-RI-RII subunit binding domain of A-kinase anchor protein

ModBase Predicted Comparative 3D Structure on P0CW23
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0034237 protein kinase A regulatory subunit binding
GO:0051018 protein kinase A binding

Biological Process:
GO:0008104 protein localization
GO:0010738 regulation of protein kinase A signaling

Cellular Component:
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
 

-  Other Names for This Gene
  Alternate Gene Symbols: C18orf42, CR042_HUMAN, ENST00000434239.1, ENST00000434239.2, ENST00000434239.3, NM_001145194, P0CW23, uc010wzc.1, uc010wzc.2, uc010wzc.3
UCSC ID: ENST00000434239.4
RefSeq Accession: NM_001145194
Protein: P0CW23 (aka CR042_HUMAN)
CCDS: CCDS54179.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.