Human Gene NFIC (ENST00000395111.7) from GENCODE V44
Description: Homo sapiens nuclear factor I C (NFIC), transcript variant 4, mRNA. (from RefSeq NM_001245005) RefSeq Summary (NM_001245005): The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]. Gencode Transcript: ENST00000395111.7 Gencode Gene: ENSG00000141905.19 Transcript (Including UTRs) Position: hg38 chr19:3,359,647-3,463,142 Size: 103,496 Total Exon Count: 10 Strand: + Coding Region Position: hg38 chr19:3,359,683-3,456,600 Size: 96,918 Coding Exon Count: 9
ID:NFIC_HUMAN DESCRIPTION: RecName: Full=Nuclear factor 1 C-type; Short=NF1-C; Short=Nuclear factor 1/C; AltName: Full=CCAAT-box-binding transcription factor; Short=CTF; AltName: Full=Nuclear factor I/C; Short=NF-I/C; Short=NFI-C; AltName: Full=TGGCA-binding protein; FUNCTION: Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. SUBUNIT: Binds DNA as a homodimer. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the CTF/NF-I family. SIMILARITY: Contains 1 CTF/NF-I DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00859 - CTF/NF-I family transcription modulation region PF03165 - MH1 domain PF10524 - Nuclear factor I protein pre-N-terminus
ModBase Predicted Comparative 3D Structure on P08651
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003690 double-stranded DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006260 DNA replication GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0042475 odontogenesis of dentin-containing tooth GO:0045892 negative regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter