Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): DPF1 CDC HuGE Published Literature: DPF1 Positive Disease Associations: Prostatic Neoplasms Related Studies:
Prostatic Neoplasms Julius Gudmundsson et al. Nature genetics 2009, Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility., Nature genetics.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF14051 - N-terminal domain of DPF2/REQ.
ModBase Predicted Comparative 3D Structure on B4DMQ8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK094632 - Homo sapiens cDNA FLJ37313 fis, clone BRAMY2016938, highly similar to ZINC-FINGER PROTEIN NEURO-D4. U43843 - Human h-neuro-d4 protein mRNA, complete cds. BC021191 - Homo sapiens D4, zinc and double PHD fingers family 1, mRNA (cDNA clone IMAGE:3162448), partial cds. AK127198 - Homo sapiens cDNA FLJ45263 fis, clone BRHIP2023735, moderately similar to Zinc-finger protein neuro-d4. BC125152 - Homo sapiens D4, zinc and double PHD fingers family 1, mRNA (cDNA clone IMAGE:40120598), complete cds. BC125153 - Homo sapiens D4, zinc and double PHD fingers family 1, mRNA (cDNA clone MGC:150429 IMAGE:40120602), complete cds. GQ358728 - Homo sapiens D4 zinc and double PHD fingers family 1 variant 4 (DPF1) mRNA, complete cds. AB463560 - Synthetic construct DNA, clone: pF1KB7695, Homo sapiens DPF1 gene for D4, zinc and double PHD fingers family 1, without stop codon, in Flexi system. AK308563 - Homo sapiens cDNA, FLJ98604. AK297581 - Homo sapiens cDNA FLJ55156 complete cds, highly similar to Zinc-finger protein neuro-d4. KJ901865 - Synthetic construct Homo sapiens clone ccsbBroadEn_11259 DPF1 gene, encodes complete protein.