Human Gene DHRS9 (ENST00000412271.1) from GENCODE V44
Description: Homo sapiens dehydrogenase/reductase 9 (DHRS9), transcript variant 4, mRNA. (from RefSeq NM_001142271) RefSeq Summary (NM_001142271): This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000412271.1 Gencode Gene: ENSG00000073737.17 Transcript (Including UTRs) Position: hg38 chr2:169,081,107-169,096,167 Size: 15,061 Total Exon Count: 5 Strand: + Coding Region Position: hg38 chr2:169,081,582-169,095,767 Size: 14,186 Coding Exon Count: 4
ID:DHRS9_HUMAN DESCRIPTION: RecName: Full=Dehydrogenase/reductase SDR family member 9; EC=1.1.-.-; AltName: Full=3-alpha hydroxysteroid dehydrogenase; Short=3-alpha-HSD; AltName: Full=NADP-dependent retinol dehydrogenase/reductase; AltName: Full=RDH-E2; AltName: Full=RDHL; AltName: Full=Short-chain dehydrogenase/reductase retSDR8; AltName: Full=Tracheobronchial epithelial cell-specific retinol dehydrogenase; Short=RDH-TBE; Flags: Precursor; FUNCTION: 3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=9 uM for NADH; KM=72 uM for NAD; KM=5 uM for allopregnanolone; KM=7.5 uM for 3-alpha-androstanediol; KM=24 uM for androsterone; KM=12 uM for dihydrotestosterone; SUBUNIT: Homotetramer (By similarity). SUBCELLULAR LOCATION: Microsome membrane. Endoplasmic reticulum membrane (Potential). Note=Associated with microsomal membranes. TISSUE SPECIFICITY: Highly expressed in trachea and epidermis. Detected at lower levels in spinal cord, bone marrow, brain, tongue, esophagus, heart, colon, testis, placenta, lung, skeletal muscle and lymph node. SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BPW9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Sequence and Links to Tools and Databases 
Microarray Expression Data 
