Human Gene NPBWR2 (ENST00000369768.1) from GENCODE V44
Description: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. (from UniProt P48146) Gencode Transcript: ENST00000369768.1 Gencode Gene: ENSG00000125522.4 Transcript (Including UTRs) Position: hg38 chr20:64,105,820-64,107,171 Size: 1,352 Total Exon Count: 1 Strand: - Coding Region Position: hg38 chr20:64,105,830-64,106,831 Size: 1,002 Coding Exon Count: 1
ID:NPBW2_HUMAN DESCRIPTION: RecName: Full=Neuropeptides B/W receptor type 2; AltName: Full=G-protein coupled receptor 8; FUNCTION: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Detected at high levels in caudate nucleus, hyppocampus and amygdala; at moderate levels in the adult brain, thalamus, parietal cortex, pituitary gland, adrenal gland and lymph nodes. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48146
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein P48146 (Reactome details) participates in the following event(s):
R-HSA-374787 GPCR neuropeptide receptor binds neuropeptides B and W R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-375276 Peptide ligand-binding receptors R-HSA-418594 G alpha (i) signalling events R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signalling R-HSA-500792 GPCR ligand binding R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction
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