Human Gene TSEN2 (ENST00000444864.6) from GENCODE V44
Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt H7C2Z3) RefSeq Summary (NM_001321278): This gene encodes one of the subunits of the tRNA splicing endonuclease. This endonuclease catalyzes the first step in RNA splicing which is the removal of introns. Mutations in this gene have been associated with pontocerebellar hypoplasia type 2. A pseudogene has been identified on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2009]. Gencode Transcript: ENST00000444864.6 Gencode Gene: ENSG00000154743.19 Transcript (Including UTRs) Position: hg38 chr3:12,484,563-12,539,610 Size: 55,048 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr3:12,489,801-12,539,373 Size: 49,573 Coding Exon Count: 10
ID:H7C2Z3_HUMAN DESCRIPTION: SubName: Full=tRNA-splicing endonuclease subunit Sen2; Flags: Fragment; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on H7C2Z3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.