Human Gene PGM2 (ENST00000381967.9) from GENCODE V44
Description: Homo sapiens phosphoglucomutase 2 (PGM2), mRNA. (from RefSeq NM_018290)
Gencode Transcript: ENST00000381967.9
Gencode Gene: ENSG00000169299.14
Transcript (Including UTRs)
Position: hg38 chr4:37,826,686-37,862,937 Size: 36,252 Total Exon Count: 14 Strand: +
Coding Region
Position: hg38 chr4:37,826,733-37,861,612 Size: 34,880 Coding Exon Count: 14
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: PGM2_HUMAN
DESCRIPTION: RecName: Full=Phosphoglucomutase-2; Short=PGM 2; EC=5.4.2.2; AltName: Full=Glucose phosphomutase 2; AltName: Full=Phosphodeoxyribomutase; AltName: Full=Phosphopentomutase; EC=5.4.2.7;
FUNCTION: Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity.CATALYTIC ACTIVITY: Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.CATALYTIC ACTIVITY: Alpha-D-ribose 1-phosphate = D-ribose 5- phosphate.CATALYTIC ACTIVITY: 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy- alpha-D-ribose 5-phosphate.COFACTOR: Binds 1 magnesium ion per subunit (By similarity).BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=45.7 uM for alpha-D-ribose 1-phosphate; KM=4.1 uM for 2-deoxy-alpha-D-ribose 1-phosphate; KM=114 uM for alpha-D-glucose 1-phosphate; Vmax=104.3 umol/min/mg enzyme with alpha-D-ribose 1-phosphate as substrate; Vmax=20.8 umol/min/mg enzyme with 2-deoxy-alpha-D-ribose 1- phosphate as substrate; Vmax=22.8 umol/min/mg enzyme with alpha-D-glucose 1-phosphate as substrate;PATHWAY: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2- deoxy-alpha-D-ribose 1-phosphate: step 1/2.SUBCELLULAR LOCATION: Cytoplasm (By similarity).SIMILARITY: Belongs to the phosphohexose mutase family.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR005844 - A-D-PHexomutase_a/b/a-I
IPR016055 - A-D-PHexomutase_a/b/a-I/II/III
IPR005845 - A-D-PHexomutase_a/b/a-II
IPR005846 - A-D-PHexomutase_a/b/a-III
IPR005843 - A-D-PHexomutase_C
IPR016066 - A-D-PHexomutase_CS
IPR005841 - Alpha-D-phosphohexomutase_SF
Pfam Domains: PF02878 - Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02879 - Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02880 - Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF00408 - Phosphoglucomutase/phosphomannomutase, C-terminal domain
ModBase Predicted Comparative 3D Structure on Q96G03
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AL136705 - Homo sapiens mRNA; cDNA DKFZp566B1524 (from clone DKFZp566B1524).AK310927 - Homo sapiens cDNA, FLJ17969.AK223237 - Homo sapiens mRNA for phosphoglucomutase 2 variant, clone: STM00936.AK303374 - Homo sapiens cDNA FLJ60384 complete cds, highly similar to Phosphoglucomutase-2 (EC 5.4.2.2).BC010087 - Homo sapiens phosphoglucomutase 2, mRNA (cDNA clone MGC:19508 IMAGE:2964390), complete cds.AF109360 - Homo sapiens MSTP006 mRNA, complete cds.AK297752 - Homo sapiens cDNA FLJ54368 complete cds, highly similar to Phosphoglucomutase-2 (EC 5.4.2.2).AK001845 - Homo sapiens cDNA FLJ10983 fis, clone PLACE1001781, weakly similar to PROBABLE PHOSPHOMANNOMUTASE (EC 5.4.2.8).CU679607 - Synthetic construct Homo sapiens gateway clone IMAGE:100019940 5' read PGM2 mRNA.KJ904801 - Synthetic construct Homo sapiens clone ccsbBroadEn_14195 PGM2-like gene, encodes complete protein.CR457274 - Homo sapiens full open reading frame cDNA clone RZPDo834A056D for gene PGM2, phosphoglucomutase 2; complete cds, incl. stopcodon.JD360769 - Sequence 341793 from Patent EP1572962.JD037949 - Sequence 18973 from Patent EP1572962.JD305894 - Sequence 286918 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ENST00000381967.1, ENST00000381967.2, ENST00000381967.3, ENST00000381967.4, ENST00000381967.5, ENST00000381967.6, ENST00000381967.7, ENST00000381967.8, MSTP006, NM_018290, PGM2_HUMAN, Q53FP5, Q5QTR0, Q96G03, Q9H0P9, Q9NV22, uc011byb.1, uc011byb.2, uc011byb.3UCSC ID: ENST00000381967.9RefSeq Accession: NM_018290
Protein: Q96G03
(aka PGM2_HUMAN)
CCDS: CCDS3443.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.