Human Gene PGM2 (ENST00000381967.9) from GENCODE V44
  Description: Homo sapiens phosphoglucomutase 2 (PGM2), mRNA. (from RefSeq NM_018290)
Gencode Transcript: ENST00000381967.9
Gencode Gene: ENSG00000169299.14
Transcript (Including UTRs)
   Position: hg38 chr4:37,826,686-37,862,937 Size: 36,252 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg38 chr4:37,826,733-37,861,612 Size: 34,880 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:37,826,686-37,862,937)mRNA (may differ from genome)Protein (612 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
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HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PGM2_HUMAN
DESCRIPTION: RecName: Full=Phosphoglucomutase-2; Short=PGM 2; EC=5.4.2.2; AltName: Full=Glucose phosphomutase 2; AltName: Full=Phosphodeoxyribomutase; AltName: Full=Phosphopentomutase; EC=5.4.2.7;
FUNCTION: Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity.
CATALYTIC ACTIVITY: Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
CATALYTIC ACTIVITY: Alpha-D-ribose 1-phosphate = D-ribose 5- phosphate.
CATALYTIC ACTIVITY: 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy- alpha-D-ribose 5-phosphate.
COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=45.7 uM for alpha-D-ribose 1-phosphate; KM=4.1 uM for 2-deoxy-alpha-D-ribose 1-phosphate; KM=114 uM for alpha-D-glucose 1-phosphate; Vmax=104.3 umol/min/mg enzyme with alpha-D-ribose 1-phosphate as substrate; Vmax=20.8 umol/min/mg enzyme with 2-deoxy-alpha-D-ribose 1- phosphate as substrate; Vmax=22.8 umol/min/mg enzyme with alpha-D-glucose 1-phosphate as substrate;
PATHWAY: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2- deoxy-alpha-D-ribose 1-phosphate: step 1/2.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the phosphohexose mutase family.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.39 RPKM in Esophagus - Mucosa
Total median expression: 352.08 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.4047-0.285 Picture PostScript Text
3' UTR -263.901325-0.199 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005844 - A-D-PHexomutase_a/b/a-I
IPR016055 - A-D-PHexomutase_a/b/a-I/II/III
IPR005845 - A-D-PHexomutase_a/b/a-II
IPR005846 - A-D-PHexomutase_a/b/a-III
IPR005843 - A-D-PHexomutase_C
IPR016066 - A-D-PHexomutase_CS
IPR005841 - Alpha-D-phosphohexomutase_SF

Pfam Domains:
PF02878 - Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
PF02879 - Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II
PF02880 - Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
PF00408 - Phosphoglucomutase/phosphomannomutase, C-terminal domain

ModBase Predicted Comparative 3D Structure on Q96G03
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologGenome BrowserGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
MGIRGDEnsembl WormBaseSGD
Protein SequenceProtein SequenceProtein Sequence Protein SequenceProtein Sequence
AlignmentAlignmentAlignment AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000287 magnesium ion binding
GO:0004614 phosphoglucomutase activity
GO:0005515 protein binding
GO:0008973 phosphopentomutase activity
GO:0016853 isomerase activity
GO:0016868 intramolecular transferase activity, phosphotransferases
GO:0046872 metal ion binding

Biological Process:
GO:0005975 carbohydrate metabolic process
GO:0005978 glycogen biosynthetic process
GO:0005980 glycogen catabolic process
GO:0006006 glucose metabolic process
GO:0006098 pentose-phosphate shunt
GO:0019388 galactose catabolic process
GO:0043312 neutrophil degranulation
GO:0046386 deoxyribose phosphate catabolic process
GO:0071704 organic substance metabolic process

Cellular Component:
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0034774 secretory granule lumen
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen


-  Descriptions from all associated GenBank mRNAs
  AL136705 - Homo sapiens mRNA; cDNA DKFZp566B1524 (from clone DKFZp566B1524).
AK310927 - Homo sapiens cDNA, FLJ17969.
AK223237 - Homo sapiens mRNA for phosphoglucomutase 2 variant, clone: STM00936.
AK303374 - Homo sapiens cDNA FLJ60384 complete cds, highly similar to Phosphoglucomutase-2 (EC 5.4.2.2).
BC010087 - Homo sapiens phosphoglucomutase 2, mRNA (cDNA clone MGC:19508 IMAGE:2964390), complete cds.
AF109360 - Homo sapiens MSTP006 mRNA, complete cds.
AK297752 - Homo sapiens cDNA FLJ54368 complete cds, highly similar to Phosphoglucomutase-2 (EC 5.4.2.2).
AK001845 - Homo sapiens cDNA FLJ10983 fis, clone PLACE1001781, weakly similar to PROBABLE PHOSPHOMANNOMUTASE (EC 5.4.2.8).
CU679607 - Synthetic construct Homo sapiens gateway clone IMAGE:100019940 5' read PGM2 mRNA.
KJ904801 - Synthetic construct Homo sapiens clone ccsbBroadEn_14195 PGM2-like gene, encodes complete protein.
CR457274 - Homo sapiens full open reading frame cDNA clone RZPDo834A056D for gene PGM2, phosphoglucomutase 2; complete cds, incl. stopcodon.
JD360769 - Sequence 341793 from Patent EP1572962.
JD037949 - Sequence 18973 from Patent EP1572962.
JD305894 - Sequence 286918 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00010 - Glycolysis / Gluconeogenesis
hsa00030 - Pentose phosphate pathway
hsa00052 - Galactose metabolism
hsa00500 - Starch and sucrose metabolism
hsa00520 - Amino sugar and nucleotide sugar metabolism
hsa01100 - Metabolic pathways

BioCyc Knowledge Library
PWY-5661-1 - GDP-glucose biosynthesis II
PWY-5941 - glycogenolysis
PWY-7180 - 2'-deoxy-α-D-ribose 1-phosphate degradation
PWY-7343 - UDP-α-D-glucose biosynthesis I
PWY0-1296 - purine ribonucleosides degradation to ribose-1-phosphate
PWY66-422 - D-galactose degradation V (Leloir pathway)

Reactome (by CSHL, EBI, and GO)

Protein Q96G03 (Reactome details) participates in the following event(s):

R-HSA-6800434 Exocytosis of ficolin-rich granule lumen proteins
R-HSA-6798748 Exocytosis of secretory granule lumen proteins
R-HSA-6787329 PGM2:Mg2+ isomerises R1P to R5P
R-HSA-8982667 PGM2:Mg2+ isomerises dR1P to dR5P
R-HSA-70272 PGM:Mg2+ isomerise G6P to G1P
R-HSA-70427 PGM:Mg2+ isomerise G1P to G6P
R-HSA-6798695 Neutrophil degranulation
R-HSA-71336 Pentose phosphate pathway (hexose monophosphate shunt)
R-HSA-168249 Innate Immune System
R-HSA-3322077 Glycogen synthesis
R-HSA-70221 Glycogen breakdown (glycogenolysis)
R-HSA-70370 Galactose catabolism
R-HSA-71387 Metabolism of carbohydrates
R-HSA-168256 Immune System
R-HSA-8982491 Glycogen metabolism
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000381967.1, ENST00000381967.2, ENST00000381967.3, ENST00000381967.4, ENST00000381967.5, ENST00000381967.6, ENST00000381967.7, ENST00000381967.8, MSTP006, NM_018290, PGM2_HUMAN, Q53FP5, Q5QTR0, Q96G03, Q9H0P9, Q9NV22, uc011byb.1, uc011byb.2, uc011byb.3
UCSC ID: ENST00000381967.9
RefSeq Accession: NM_018290
Protein: Q96G03 (aka PGM2_HUMAN)
CCDS: CCDS3443.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.