Human Gene GUCY1B1 (ENST00000505764.5) from GENCODE V44
Description: Homo sapiens guanylate cyclase 1 soluble subunit beta 1 (GUCY1B1), transcript variant 3, mRNA. (from RefSeq NM_001291952) RefSeq Summary (NM_001291952): This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. Gencode Transcript: ENST00000505764.5 Gencode Gene: ENSG00000061918.14 Transcript (Including UTRs) Position: hg38 chr4:155,759,026-155,806,738 Size: 47,713 Total Exon Count: 15 Strand: + Coding Region Position: hg38 chr4:155,772,737-155,806,409 Size: 33,673 Coding Exon Count: 13
ID:GCYB1_HUMAN DESCRIPTION: RecName: Full=Guanylate cyclase soluble subunit beta-1; Short=GCS-beta-1; EC=4.6.1.2; AltName: Full=Guanylate cyclase soluble subunit beta-3; Short=GCS-beta-3; AltName: Full=Soluble guanylate cyclase small subunit; CATALYTIC ACTIVITY: GTP = 3',5'-cyclic GMP + diphosphate. COFACTOR: Binds 1 or 2 heme groups per heterodimer (By similarity). ENZYME REGULATION: Activated by nitric oxide in the presence of magnesium or manganese ions. SUBUNIT: Heterodimer of an alpha and a beta chain. SUBCELLULAR LOCATION: Cytoplasm. MISCELLANEOUS: There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. SIMILARITY: Contains 1 guanylate cyclase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q02153
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.