Human Gene SMIM13 (ENST00000416247.4) from GENCODE V44
  Description: Homo sapiens small integral membrane protein 13 (SMIM13), mRNA. (from RefSeq NM_001135575)
Gencode Transcript: ENST00000416247.4
Gencode Gene: ENSG00000224531.6
Transcript (Including UTRs)
   Position: hg38 chr6:11,093,834-11,138,733 Size: 44,900 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr6:11,094,314-11,134,602 Size: 40,289 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:11,093,834-11,138,733)mRNA (may differ from genome)Protein (91 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
HPRDLynxMGIneXtProtPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CF228_HUMAN
DESCRIPTION: RecName: Full=UPF0766 protein C6orf228;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the UPF0766 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.88 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 273.85 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -250.90480-0.523 Picture PostScript Text
3' UTR -1042.904131-0.252 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on P0DJ93
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  KJ893930 - Synthetic construct Homo sapiens clone ccsbBroadEn_03324 TMEM14C gene, encodes complete protein.
HQ447475 - Synthetic construct Homo sapiens clone IMAGE:100070805; CCSB014338_01 transmembrane protein 14B (TMEM14B) gene, encodes complete protein.
KJ894865 - Synthetic construct Homo sapiens clone ccsbBroadEn_04259 TMEM14B gene, encodes complete protein.
KJ899695 - Synthetic construct Homo sapiens clone ccsbBroadEn_09089 TMEM14B gene, encodes complete protein.
AK058186 - Homo sapiens cDNA FLJ25457 fis, clone TST08959.
BC032356 - Homo sapiens cDNA clone IMAGE:5219435.
JD484872 - Sequence 465896 from Patent EP1572962.
JD461540 - Sequence 442564 from Patent EP1572962.
JD138585 - Sequence 119609 from Patent EP1572962.
JD443368 - Sequence 424392 from Patent EP1572962.
JD275865 - Sequence 256889 from Patent EP1572962.
JD235691 - Sequence 216715 from Patent EP1572962.
JD098490 - Sequence 79514 from Patent EP1572962.
AK299804 - Homo sapiens cDNA FLJ53537 complete cds.
JD202458 - Sequence 183482 from Patent EP1572962.
JD296618 - Sequence 277642 from Patent EP1572962.
AJ420516 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 966164.
AK129879 - Homo sapiens cDNA FLJ26369 fis, clone HRT06001.

-  Other Names for This Gene
  Alternate Gene Symbols: C6orf228, CF228_HUMAN, ENST00000416247.1, ENST00000416247.2, ENST00000416247.3, G3V581, NM_001135575, P0DJ93, uc011dio.1, uc011dio.2, uc011dio.3, uc011dio.4
UCSC ID: ENST00000416247.4
RefSeq Accession: NM_001135575
Protein: P0DJ93 (aka CF228_HUMAN)
CCDS: CCDS56396.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.