Human Gene BCLAF1 (ENST00000527759.5) from GENCODE V44
Description: Homo sapiens BCL2 associated transcription factor 1 (BCLAF1), transcript variant 4, mRNA. (from RefSeq NM_001301038) RefSeq Summary (NM_001301038): This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000527759.5 Gencode Gene: ENSG00000029363.17 Transcript (Including UTRs) Position: hg38 chr6:136,259,691-136,289,795 Size: 30,105 Total Exon Count: 13 Strand: - Coding Region Position: hg38 chr6:136,261,110-136,279,866 Size: 18,757 Coding Exon Count: 11
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NYF8
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006915 apoptotic process GO:0043065 positive regulation of apoptotic process GO:0043620 regulation of DNA-templated transcription in response to stress GO:0045892 negative regulation of transcription, DNA-templated GO:1990830 cellular response to leukemia inhibitory factor GO:2000144 positive regulation of DNA-templated transcription, initiation GO:2001022 positive regulation of response to DNA damage stimulus GO:2001244 positive regulation of intrinsic apoptotic signaling pathway