Human Gene SLC7A2 (ENST00000522656.5) from GENCODE V44
Description: Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages (By similarity). (from UniProt P52569) RefSeq Summary (NM_001008539): The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000522656.5 Gencode Gene: ENSG00000003989.18 Transcript (Including UTRs) Position: hg38 chr8:17,497,091-17,565,274 Size: 68,184 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chr8:17,543,340-17,565,146 Size: 21,807 Coding Exon Count: 11
ID:CTR2_HUMAN DESCRIPTION: RecName: Full=Low affinity cationic amino acid transporter 2; Short=CAT-2; Short=CAT2; AltName: Full=Solute carrier family 7 member 2; FUNCTION: Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart. SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. SEQUENCE CAUTION: Sequence=AAH69648.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI04906.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI13662.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI43584.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P52569
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002537 nitric oxide production involved in inflammatory response GO:0006520 cellular amino acid metabolic process GO:0006809 nitric oxide biosynthetic process GO:0006865 amino acid transport GO:0015809 arginine transport GO:0042116 macrophage activation GO:0043030 regulation of macrophage activation GO:0050727 regulation of inflammatory response GO:0055085 transmembrane transport GO:0097638 L-arginine import across plasma membrane GO:0097639 L-lysine import across plasma membrane GO:0097640 L-ornithine import across plasma membrane GO:1902023 L-arginine transport GO:1903352 L-ornithine transmembrane transport
AK314287 - Homo sapiens cDNA, FLJ95043. U76368 - Human cationic amino acid transporter-2A (ATRC2) mRNA, complete cds. BC069648 - Homo sapiens solute carrier family 7 (cationic amino acid transporter, y+ system), member 2, mRNA (cDNA clone MGC:97225 IMAGE:7262473), complete cds. BC113661 - Homo sapiens solute carrier family 7 (cationic amino acid transporter, y+ system), member 2, mRNA (cDNA clone MGC:142221 IMAGE:8322713), complete cds. BC104905 - Homo sapiens solute carrier family 7 (cationic amino acid transporter, y+ system), member 2, mRNA (cDNA clone MGC:132565 IMAGE:8143908), complete cds. BC143583 - Homo sapiens solute carrier family 7 (cationic amino acid transporter, y+ system), member 2, mRNA (cDNA clone MGC:177111 IMAGE:9052094), complete cds. KJ901743 - Synthetic construct Homo sapiens clone ccsbBroadEn_11137 SLC7A2 gene, encodes complete protein. D29990 - Homo sapiens mRNA for cationic amino acid transporter 2, complete cds. AL832016 - Homo sapiens mRNA; cDNA DKFZp451F074 (from clone DKFZp451F074). U76369 - Human cationic amino acid transporter-2B (ATRC2) mRNA, partial cds.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P52569 (Reactome details) participates in the following event(s):
R-HSA-375768 Metabolism of nitrogenous molecules R-HSA-352230 Amino acid transport across the plasma membrane R-HSA-425374 Amino acid and oligopeptide SLC transporters R-HSA-425393 Metabolism of nitrogenous molecules R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules R-HSA-375790 Metabolism of nitrogenous molecules R-HSA-352230 Amino acid transport across the plasma membrane R-HSA-425374 Amino acid and oligopeptide SLC transporters R-HSA-425393 Metabolism of nitrogenous molecules R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules