Description: Homo sapiens Kruppel like factor 10 (KLF10), transcript variant 1, mRNA. (from RefSeq NM_005655) RefSeq Summary (NM_005655): This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]. Gencode Transcript: ENST00000285407.11 Gencode Gene: ENSG00000155090.15 Transcript (Including UTRs) Position: hg38 chr8:102,648,784-102,655,725 Size: 6,942 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr8:102,650,132-102,655,601 Size: 5,470 Coding Exon Count: 4
ID:KLF10_HUMAN DESCRIPTION: RecName: Full=Krueppel-like factor 10; AltName: Full=EGR-alpha; AltName: Full=Transforming growth factor-beta-inducible early growth response protein 1; Short=TGFB-inducible early growth response protein 1; Short=TIEG-1; FUNCTION: Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'. INTERACTION: P08047:SP1; NbExp=2; IntAct=EBI-1389509, EBI-298336; SUBCELLULAR LOCATION: Nucleus. INDUCTION: By TGFB1. PTM: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (Probable). SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family. SIMILARITY: Contains 3 C2H2-type zinc fingers.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13118
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005515 protein binding GO:0046872 metal ion binding