Human Gene KLF10 (ENST00000285407.11)
  Description: Homo sapiens Kruppel like factor 10 (KLF10), transcript variant 1, mRNA. (from RefSeq NM_005655)
RefSeq Summary (NM_005655): This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].
Gencode Transcript: ENST00000285407.11
Gencode Gene: ENSG00000155090.15
Transcript (Including UTRs)
   Position: hg38 chr8:102,648,784-102,655,725 Size: 6,942 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr8:102,650,132-102,655,601 Size: 5,470 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesGeneReviewsMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:102,648,784-102,655,725)mRNA (may differ from genome)Protein (480 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: KLF10_HUMAN
DESCRIPTION: RecName: Full=Krueppel-like factor 10; AltName: Full=EGR-alpha; AltName: Full=Transforming growth factor-beta-inducible early growth response protein 1; Short=TGFB-inducible early growth response protein 1; Short=TIEG-1;
FUNCTION: Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'.
INTERACTION: P08047:SP1; NbExp=2; IntAct=EBI-1389509, EBI-298336;
SUBCELLULAR LOCATION: Nucleus.
INDUCTION: By TGFB1.
PTM: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (Probable).
SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
SIMILARITY: Contains 3 C2H2-type zinc fingers.

-  MalaCards Disease Associations
  MalaCards Gene Search: KLF10
Diseases sorted by gene-association score: hemoglobinopathy (8), pancreatic cancer (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 43.42 RPKM in Muscle - Skeletal
Total median expression: 743.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -55.80124-0.450 Picture PostScript Text
3' UTR -343.301348-0.255 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2EPA
- NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q13118
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007623 circadian rhythm
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009267 cellular response to starvation
GO:0030282 bone mineralization
GO:0035019 somatic stem cell population maintenance
GO:0042752 regulation of circadian rhythm
GO:0045672 positive regulation of osteoclast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048511 rhythmic process
GO:1901653 cellular response to peptide

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF210253 - JP 2014500723-A/17756: Polycomb-Associated Non-Coding RNAs.
MA445830 - JP 2018138019-A/17756: Polycomb-Associated Non-Coding RNAs.
LF214022 - JP 2014500723-A/21525: Polycomb-Associated Non-Coding RNAs.
MA449599 - JP 2018138019-A/21525: Polycomb-Associated Non-Coding RNAs.
BC011538 - Homo sapiens Kruppel-like factor 10, mRNA (cDNA clone MGC:9118 IMAGE:3868209), complete cds.
BC095399 - Homo sapiens Kruppel-like factor 10, mRNA (cDNA clone MGC:110869 IMAGE:30520399), complete cds.
X75691 - H.sapiens (TL25) mRNA from LNCaP cell line.
S81439 - EGR alpha=early growth response gene alpha [human, prostate, mRNA, 3228 nt].
U21847 - Human TGF-beta inducible early protein (TIEG) mRNA, complete cds.
JD565734 - Sequence 546758 from Patent EP1572962.
JD566982 - Sequence 548006 from Patent EP1572962.
LF336183 - JP 2014500723-A/143686: Polycomb-Associated Non-Coding RNAs.
MA571760 - JP 2018138019-A/143686: Polycomb-Associated Non-Coding RNAs.
LF336184 - JP 2014500723-A/143687: Polycomb-Associated Non-Coding RNAs.
MA571761 - JP 2018138019-A/143687: Polycomb-Associated Non-Coding RNAs.
JD086929 - Sequence 67953 from Patent EP1572962.
JD258673 - Sequence 239697 from Patent EP1572962.
LF336185 - JP 2014500723-A/143688: Polycomb-Associated Non-Coding RNAs.
MA571762 - JP 2018138019-A/143688: Polycomb-Associated Non-Coding RNAs.
JD429677 - Sequence 410701 from Patent EP1572962.
LF336186 - JP 2014500723-A/143689: Polycomb-Associated Non-Coding RNAs.
MA571763 - JP 2018138019-A/143689: Polycomb-Associated Non-Coding RNAs.
JD512929 - Sequence 493953 from Patent EP1572962.
JD453544 - Sequence 434568 from Patent EP1572962.
HF546210 - Homo sapiens mRNA for Kruppel-like factor 10, splice variant 1 (KLF10 gene).
HF546211 - Homo sapiens mRNA for Kruppel-like factor 10, splice variant 2 (KLF10 gene).
JD375712 - Sequence 356736 from Patent EP1572962.
LF336187 - JP 2014500723-A/143690: Polycomb-Associated Non-Coding RNAs.
MA571764 - JP 2018138019-A/143690: Polycomb-Associated Non-Coding RNAs.
JD380182 - Sequence 361206 from Patent EP1572962.
EU832176 - Synthetic construct Homo sapiens clone HAIB:100067205; DKFZo008H0725 Kruppel-like factor 10 protein (KLF10) gene, encodes complete protein.
AK312894 - Homo sapiens cDNA, FLJ93338, Homo sapiens TGFB inducible early growth response (TIEG), mRNA.
EU832269 - Synthetic construct Homo sapiens clone HAIB:100067298; DKFZo004H0726 Kruppel-like factor 10 protein (KLF10) gene, encodes complete protein.
HQ448295 - Synthetic construct Homo sapiens clone IMAGE:100071699; CCSB002992_03 Kruppel-like factor 10 (KLF10) gene, encodes complete protein.
KJ897673 - Synthetic construct Homo sapiens clone ccsbBroadEn_07067 KLF10 gene, encodes complete protein.
BT006634 - Homo sapiens TGFB inducible early growth response mRNA, complete cds.
AB384883 - Synthetic construct DNA, clone: pF1KB4014, Homo sapiens KLF10 gene for krueppel-like factor 10, complete cds, without stop codon, in Flexi system.
LF336188 - JP 2014500723-A/143691: Polycomb-Associated Non-Coding RNAs.
MA571765 - JP 2018138019-A/143691: Polycomb-Associated Non-Coding RNAs.
LF336189 - JP 2014500723-A/143692: Polycomb-Associated Non-Coding RNAs.
MA571766 - JP 2018138019-A/143692: Polycomb-Associated Non-Coding RNAs.
LF336190 - JP 2014500723-A/143693: Polycomb-Associated Non-Coding RNAs.
MA571767 - JP 2018138019-A/143693: Polycomb-Associated Non-Coding RNAs.
JD188760 - Sequence 169784 from Patent EP1572962.
JD361287 - Sequence 342311 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8MVH0, B2R794, ENST00000285407.1, ENST00000285407.10, ENST00000285407.2, ENST00000285407.3, ENST00000285407.4, ENST00000285407.5, ENST00000285407.6, ENST00000285407.7, ENST00000285407.8, ENST00000285407.9, KLF10_HUMAN, NM_005655, O75411, Q13118, Q503B2, TIEG, TIEG1, uc011lhk.1, uc011lhk.2, uc011lhk.3, uc011lhk.4
UCSC ID: ENST00000285407.11
RefSeq Accession: NM_005655
Protein: Q13118 (aka KLF10_HUMAN or KLFA_HUMAN)
CCDS: CCDS6294.1, CCDS47905.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene KLF10:
hyper-card (Hypertrophic Cardiomyopathy Overview)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.