Human Gene OR2S2 (ENST00000341959.2) from GENCODE V44
Description: Homo sapiens olfactory receptor family 2 subfamily S member 2 (OR2S2), mRNA. (from RefSeq NM_019897) RefSeq Summary (NM_019897): Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]. Sequence Note: This gene is a segregating pseudogene. This RefSeq represents the protein encoded by the reference genome allele, which is predicted to be functional according to the Classifier for Olfactory Receptor Pseudogenes. CCDS Note: This olfactory receptor gene is a segregating pseudogene (PMID:22908908), where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele that is predicted to be non-functional. This CCDS is being retained because the Classifier for Olfactory Receptor Pseudogenes (CORP) predicts the reference genome allele to be functional. Gencode Transcript: ENST00000341959.2 Gencode Gene: ENSG00000278889.4 Transcript (Including UTRs) Position: hg38 chr9:35,957,108-35,958,154 Size: 1,047 Total Exon Count: 1 Strand: - Coding Region Position: hg38 chr9:35,957,139-35,958,098 Size: 960 Coding Exon Count: 1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NQN1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007608 sensory perception of smell GO:0050896 response to stimulus GO:0050911 detection of chemical stimulus involved in sensory perception of smell