ID:TLE4_HUMAN DESCRIPTION: RecName: Full=Transducin-like enhancer protein 4; FUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). SUBUNIT: Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2. Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: In all tissues examined, mostly in brain, and muscle. PTM: Phosphorylated. PAX5 binding increases phosphorylation (By similarity). PTM: Ubiquitinated by XIAP/BIRC4. SIMILARITY: Belongs to the WD repeat Groucho/TLE family. SIMILARITY: Contains 7 WD repeats. SEQUENCE CAUTION: Sequence=BAA86575.1; Type=Erroneous initiation; Sequence=CAC22598.1; Type=Erroneous gene model prediction; Sequence=CAC22599.1; Type=Erroneous gene model prediction; Sequence=CAI13644.1; Type=Erroneous gene model prediction; Sequence=CAI13734.1; Type=Erroneous gene model prediction; Sequence=CAI41315.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q04727
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.