Human Gene SET (ENST00000372688.9) from GENCODE V44
Description: SET nuclear proto-oncogene (from HGNC SET) RefSeq Summary (NM_003011): The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. Gencode Transcript: ENST00000372688.9 Gencode Gene: ENSG00000119335.18 Transcript (Including UTRs) Position: hg38 chr9:128,689,538-128,694,728 Size: 5,191 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr9:128,689,583-128,694,123 Size: 4,541 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.