Mouse Gene Amer2 (ENSMUST00000022561.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity). (from UniProt Q8CCJ4) Gencode Transcript: ENSMUST00000022561.8 Gencode Gene: ENSMUSG00000021986.9 Transcript (Including UTRs) Position: mm10 chr14:60,377,692-60,388,197 Size: 10,506 Total Exon Count: 1 Strand: + Coding Region Position: mm10 chr14:60,378,247-60,380,265 Size: 2,019 Coding Exon Count: 1
ID:AMER2_MOUSE DESCRIPTION: RecName: Full=APC membrane recruitment protein 2; Short=Amer2; AltName: Full=Protein FAM123A; FUNCTION: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity). SUBUNIT: Interacts with APC (By similarity). SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity). Note=Translocates to the cell membrane following binding to PtdIns(4,5)P2 (By similarity). SIMILARITY: Belongs to the Amer family. SEQUENCE CAUTION: Sequence=AAH30356.1; Type=Erroneous initiation; Sequence=AAH56350.1; Type=Erroneous initiation; Sequence=BAB27452.1; Type=Erroneous initiation; Sequence=BAC27972.1; Type=Erroneous initiation; Sequence=BAE23912.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8CCJ4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.