Mouse Gene Add2 (ENSMUST00000203279.1) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). (from UniProt Q9QYB8) RefSeq Summary (NM_001271859): This gene encodes the beta subunit of the adducin family. Adducins, encoded by alpha, beta and gamma genes, are heteromeric proteins that crosslink actin filaments with spectrin at the cytoskeletal membrane. This protein, primarily found in the brain and hematopoietic cells, is regulated by phosphorylation and calmodulin interactions as it promotes spectrin assembly onto actin filaments, bundles actin and caps barbed ends of actin filaments. In mouse, deficiency of this gene can lead to mild hemolytic anemia and impaired synaptic plasticity. Mutations of this gene in mouse serve as a pathophysiological model for hereditary spherocytosis and hereditary elliptocytosis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Dec 2012]. Gencode Transcript: ENSMUST00000203279.1 Gencode Gene: ENSMUSG00000030000.10 Transcript (Including UTRs) Position: mm10 chr6:86,085,862-86,118,801 Size: 32,940 Total Exon Count: 9 Strand: + Coding Region Position: mm10 chr6:86,085,862-86,118,781 Size: 32,920 Coding Exon Count: 9
ID:ADDB_MOUSE DESCRIPTION: RecName: Full=Beta-adducin; AltName: Full=Add97; AltName: Full=Erythrocyte adducin subunit beta; FUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity). SUBUNIT: Heterodimer of an alpha and a beta subunit. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). DOMAIN: Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region. SIMILARITY: Belongs to the aldolase class II family. Adducin subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9QYB8
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.