Human Gene WDR11 (ENST00000263461.11) from GENCODE V44
Description: Homo sapiens WD repeat domain 11 (WDR11), mRNA. (from RefSeq NM_018117) RefSeq Summary (NM_018117): This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000263461.11 Gencode Gene: ENSG00000120008.16 Transcript (Including UTRs) Position: hg38 chr10:120,851,362-120,909,524 Size: 58,163 Total Exon Count: 29 Strand: + Coding Region Position: hg38 chr10:120,851,421-120,908,713 Size: 57,293 Coding Exon Count: 29
ID:WDR11_HUMAN DESCRIPTION: RecName: Full=WD repeat-containing protein 11; AltName: Full=Bromodomain and WD repeat-containing protein 2; AltName: Full=WD repeat-containing protein 15; SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). TISSUE SPECIFICITY: Ubiquitous. DISEASE: Note=A chromosomal aberration involving WDR11 is found in a form of glioblastoma. Translocation t(10;19)(q26;q13.3) with ZNF320. SIMILARITY: Contains 9 WD repeats. SEQUENCE CAUTION: Sequence=BAA92589.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BZH6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.