Human Gene RNF166 (uc021tmn.1) Description and Page Index
Description: Homo sapiens ring finger protein 166 (RNF166), transcript variant 3, mRNA.
Transcript (Including UTRs)
Position: hg19 chr16:88,762,903-88,770,025 Size: 7,123 Total Exon Count: 6 Strand: -
Position: hg19 chr16:88,763,976-88,766,125 Size: 2,150 Coding Exon Count: 4
Data last updated: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=RING finger protein 166;
SIMILARITY: Contains 1 RING-type zinc finger. SIMILARITY: Contains 1 UIM (ubiquitin-interacting motif) repeat.
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR008598 - Di19_RING_finger_144
IPR015880 - Znf_C2H2-like
IPR001841 - Znf_RING
IPR013083 - Znf_RING/FYVE/PHD
IPR017907 - Znf_RING_CS
Pfam Domains: PF02809 - Ubiquitin interaction motif
PF05605 - Drought induced 19 protein (Di19), zinc-binding
ModBase Predicted Comparative 3D Structure on Q96A37
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0031624 ubiquitin conjugating enzyme binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process: GO:0000209 protein polyubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component: GO:0005622 intracellular
Descriptions from all associated GenBank mRNAs
LF208346 - JP 2014500723-A/15849: Polycomb-Associated Non-Coding RNAs. LF384488 - JP 2014500723-A/191991: Polycomb-Associated Non-Coding RNAs. AK026860 - Homo sapiens cDNA: FLJ23207 fis, clone ADSE00968. BC017226 - Homo sapiens ring finger protein 166, mRNA (cDNA clone MGC:14381 IMAGE:4299817), complete cds. AK057201 - Homo sapiens cDNA FLJ32639 fis, clone SYNOV2001014, weakly similar to Mus musculus Zfp228 (Znf228) mRNA. AK057106 - Homo sapiens cDNA FLJ32544 fis, clone SMINT2000545, highly similar to RING finger protein 166. JD387216 - Sequence 368240 from Patent EP1572962. JD271617 - Sequence 252641 from Patent EP1572962. JD054396 - Sequence 35420 from Patent EP1572962. JD467391 - Sequence 448415 from Patent EP1572962. JD424330 - Sequence 405354 from Patent EP1572962. JD335032 - Sequence 316056 from Patent EP1572962. JD454144 - Sequence 435168 from Patent EP1572962. LF375077 - JP 2014500723-A/182580: Polycomb-Associated Non-Coding RNAs. BC013948 - Homo sapiens ring finger protein 166, mRNA (cDNA clone MGC:2647 IMAGE:3509621), complete cds. LF375078 - JP 2014500723-A/182581: Polycomb-Associated Non-Coding RNAs. JD101127 - Sequence 82151 from Patent EP1572962. AK290920 - Homo sapiens cDNA FLJ76164 complete cds, highly similar to Homo sapiens ring finger protein 166 (RNF166), mRNA. JD400566 - Sequence 381590 from Patent EP1572962. JD277846 - Sequence 258870 from Patent EP1572962. JD321503 - Sequence 302527 from Patent EP1572962. JD427735 - Sequence 408759 from Patent EP1572962. HQ258016 - Synthetic construct Homo sapiens clone IMAGE:100072325 ring finger protein 166 (RNF166) gene, encodes complete protein. KJ900031 - Synthetic construct Homo sapiens clone ccsbBroadEn_09425 RNF166 gene, encodes complete protein. KJ900032 - Synthetic construct Homo sapiens clone ccsbBroadEn_09426 RNF166 gene, encodes complete protein. CU680704 - Synthetic construct Homo sapiens gateway clone IMAGE:100023209 5' read RNF166 mRNA. MA620065 - JP 2018138019-A/191991: Polycomb-Associated Non-Coding RNAs. MA443923 - JP 2018138019-A/15849: Polycomb-Associated Non-Coding RNAs. MA610654 - JP 2018138019-A/182580: Polycomb-Associated Non-Coding RNAs. MA610655 - JP 2018138019-A/182581: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: B3KQ03, D3DX75, NM_001171816, NP_001165287, Q96A37, Q96DM0, RN166_HUMAN UCSC ID: uc021tmn.1 RefSeq Accession: NM_001171816
(aka RN166_HUMAN) Q96A37
Gene Model Information
6 CDS single in 3' UTR:
387 CDS single in intron:
Alignment % ID:
548.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.