Human Gene RNF166 (uc021tmo.1) Description and Page Index
  Description: Homo sapiens ring finger protein 166 (RNF166), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:88,762,903-88,772,800 Size: 9,898 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr16:88,763,976-88,772,733 Size: 8,758 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:88,762,903-88,772,800)mRNA (may differ from genome)Protein (156 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
Stanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=RING finger protein 166;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.86 RPKM in Whole Blood
Total median expression: 354.99 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -36.5067-0.545 Picture PostScript Text
3' UTR -466.801073-0.435 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008598 - Di19_RING_finger_144
IPR015880 - Znf_C2H2-like

Pfam Domains:
PF02809 - Ubiquitin interaction motif
PF05605 - Drought induced 19 protein (Di19), zinc-binding

ModBase Predicted Comparative 3D Structure on H3BTU8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Descriptions from all associated GenBank mRNAs
  LF208346 - JP 2014500723-A/15849: Polycomb-Associated Non-Coding RNAs.
LF384488 - JP 2014500723-A/191991: Polycomb-Associated Non-Coding RNAs.
AK026860 - Homo sapiens cDNA: FLJ23207 fis, clone ADSE00968.
BC017226 - Homo sapiens ring finger protein 166, mRNA (cDNA clone MGC:14381 IMAGE:4299817), complete cds.
AK057201 - Homo sapiens cDNA FLJ32639 fis, clone SYNOV2001014, weakly similar to Mus musculus Zfp228 (Znf228) mRNA.
AK057106 - Homo sapiens cDNA FLJ32544 fis, clone SMINT2000545, highly similar to RING finger protein 166.
JD387216 - Sequence 368240 from Patent EP1572962.
JD271617 - Sequence 252641 from Patent EP1572962.
JD054396 - Sequence 35420 from Patent EP1572962.
JD467391 - Sequence 448415 from Patent EP1572962.
JD424330 - Sequence 405354 from Patent EP1572962.
JD335032 - Sequence 316056 from Patent EP1572962.
JD454144 - Sequence 435168 from Patent EP1572962.
LF375077 - JP 2014500723-A/182580: Polycomb-Associated Non-Coding RNAs.
BC013948 - Homo sapiens ring finger protein 166, mRNA (cDNA clone MGC:2647 IMAGE:3509621), complete cds.
LF375078 - JP 2014500723-A/182581: Polycomb-Associated Non-Coding RNAs.
JD101127 - Sequence 82151 from Patent EP1572962.
AK290920 - Homo sapiens cDNA FLJ76164 complete cds, highly similar to Homo sapiens ring finger protein 166 (RNF166), mRNA.
JD400566 - Sequence 381590 from Patent EP1572962.
JD277846 - Sequence 258870 from Patent EP1572962.
JD321503 - Sequence 302527 from Patent EP1572962.
JD427735 - Sequence 408759 from Patent EP1572962.
HQ258016 - Synthetic construct Homo sapiens clone IMAGE:100072325 ring finger protein 166 (RNF166) gene, encodes complete protein.
KJ900031 - Synthetic construct Homo sapiens clone ccsbBroadEn_09425 RNF166 gene, encodes complete protein.
KJ900032 - Synthetic construct Homo sapiens clone ccsbBroadEn_09426 RNF166 gene, encodes complete protein.
CU680704 - Synthetic construct Homo sapiens gateway clone IMAGE:100023209 5' read RNF166 mRNA.
MA620065 - JP 2018138019-A/191991: Polycomb-Associated Non-Coding RNAs.
MA443923 - JP 2018138019-A/15849: Polycomb-Associated Non-Coding RNAs.
MA610654 - JP 2018138019-A/182580: Polycomb-Associated Non-Coding RNAs.
MA610655 - JP 2018138019-A/182581: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: H3BTU8, H3BTU8_HUMAN, NM_001171815, NP_001165286
UCSC ID: uc021tmo.1
RefSeq Accession: NM_001171815
Protein: H3BTU8 CCDS: CCDS54057.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001171815.1
exon count: 5CDS single in 3' UTR: no RNA size: 1616
ORF size: 471CDS single in intron: no Alignment % ID: 99.94
txCdsPredict score: 1034.00frame shift in genome: no % Coverage: 99.69
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.