Human Gene SP6 (uc021tzc.1) Description and Page Index
  Description: Homo sapiens Sp6 transcription factor (SP6), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:45,924,665-45,925,795 Size: 1,131 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr17:45,924,665-45,925,795 Size: 1,131 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesMicroarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:45,924,665-45,925,795)mRNA (may differ from genome)Protein (376 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
CGAPEntrez GeneExonPrimerGeneCardsHGNCLynx
MGIneXtProtOMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: SP6_HUMAN
DESCRIPTION: RecName: Full=Transcription factor Sp6; AltName: Full=Krueppel-like factor 14;
FUNCTION: Promotes cell proliferation (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
SIMILARITY: Contains 3 C2H2-type zinc fingers.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SP6
CDC HuGE Published Literature: SP6

-  MalaCards Disease Associations
  MalaCards Gene Search: SP6
Diseases sorted by gene-association score: hermansky-pudlak syndrome 6 (4), bladder neck obstruction (2), premenstrual tension (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q3SY56
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0008284 positive regulation of cell proliferation
GO:0042481 regulation of odontogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK127707 - Homo sapiens cDNA FLJ45807 fis, clone NT2RI3009480, highly similar to Transcription factor Sp6.
AK127850 - Homo sapiens cDNA FLJ45953 fis, clone PLACE7009757, highly similar to Transcription factor Sp6.
BC103951 - Homo sapiens Sp6 transcription factor, mRNA (cDNA clone MGC:119662 IMAGE:40011121), complete cds.
BC103952 - Homo sapiens Sp6 transcription factor, mRNA (cDNA clone MGC:119663 IMAGE:40011125), complete cds.
BC103953 - Homo sapiens Sp6 transcription factor, mRNA (cDNA clone MGC:119664 IMAGE:40011129), complete cds.
BC103954 - Homo sapiens Sp6 transcription factor, mRNA (cDNA clone MGC:119665 IMAGE:40011132), complete cds.
KJ894814 - Synthetic construct Homo sapiens clone ccsbBroadEn_04208 SP6 gene, encodes complete protein.
AB464709 - Synthetic construct DNA, clone: pF1KB9848, Homo sapiens SP6 gene for Sp6 transcription factor, without stop codon, in Flexi system.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KXS4, CCDS11520, KLF14, NM_199262, NP_954871, Q3SY56, SP6_HUMAN
UCSC ID: uc021tzc.1
Representative RNA: CCDS11520 Protein: Q3SY56 (aka SP6_HUMAN)
CCDS: CCDS11520.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: CCDS11520.1
exon count: 1CDS single in 3' UTR: no RNA size: 1131
ORF size: 1131CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2362.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.