Human Gene GNGT2 (uc021tzo.1) Description and Page Index
Description: Homo sapiens guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 (GNGT2), transcript variant 4, mRNA. RefSeq Summary (NM_001198756): Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]. Transcript (Including UTRs) Position: hg19 chr17:47,283,596-47,286,762 Size: 3,167 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr17:47,284,119-47,284,784 Size: 666 Coding Exon Count: 2
ID:GBGT2_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2; AltName: Full=G gamma-C; AltName: Full=G-gamma-8; AltName: Full=G-gamma-9; AltName: Full=Guanine nucleotide binding protein gamma transducing activity polypeptide 2; Flags: Precursor; FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). TISSUE SPECIFICITY: Retinal cones. SIMILARITY: Belongs to the G protein gamma family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 48670 - Transducin (heterotrimeric G protein), gamma chain
ModBase Predicted Comparative 3D Structure on O14610
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.