Human Gene ZNF71 (uc021vcg.1) Description and Page Index
  Description: Homo sapiens zinc finger protein 71 (ZNF71), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:57,132,656-57,134,125 Size: 1,470 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr19:57,132,656-57,134,125 Size: 1,470 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesMicroarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:57,132,656-57,134,125)mRNA (may differ from genome)Protein (489 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaCGAP
Entrez GeneExonPrimerGeneCardsH-INVHGNCHPRD
LynxMGIneXtProtOMIMPubMedReactome
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: ZNF71_HUMAN
DESCRIPTION: RecName: Full=Endothelial zinc finger protein induced by tumor necrosis factor alpha; AltName: Full=Zinc finger protein 71;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
TISSUE SPECIFICITY: Highly expressed in placenta, followed by brain, testis, pancreas, heart, small intestine, muscle, uterus, prostate and peripheral blood leukocytes. Not detected in liver, lung, colon, stomach, salivary and thyroid gland.
INDUCTION: By TNF.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 13 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=AAD23608.1; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF71
CDC HuGE Published Literature: ZNF71

-  MalaCards Disease Associations
  MalaCards Gene Search: ZNF71
Diseases sorted by gene-association score: hypotrichosis 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF12874 - Zinc-finger of C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9NQZ8
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC014280 - Homo sapiens zinc finger protein 71, mRNA (cDNA clone MGC:11153 IMAGE:3840512), complete cds.
AF269249 - Homo sapiens endothelial zinc finger protein induced by tumor necrosis factor alpha (EZFIT) mRNA, complete cds.
AX721136 - Sequence 96 from Patent WO0220754.
CU676957 - Synthetic construct Homo sapiens gateway clone IMAGE:100017360 5' read ZNF71 mRNA.
AB529316 - Synthetic construct DNA, clone: pF1KB9669, Homo sapiens ZNF71 gene for zinc finger protein 71, without stop codon, in Flexi system.
KJ899385 - Synthetic construct Homo sapiens clone ccsbBroadEn_08779 ZNF71 gene, encodes complete protein.
AK057019 - Homo sapiens cDNA FLJ32457 fis, clone SKNMC1000026, highly similar to Homo sapiens endothelial zinc finger protein induced by tumor necrosis factor alpha (EZFIT) mRNA.
DL492511 - Novel nucleic acids.
DL490980 - Novel nucleic acids.
DL490980 - Novel nucleic acids.
DL491906 - Novel nucleic acids.
DL490469 - Novel nucleic acids.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NQZ8 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: CCDS12947, EZFIT, NM_021216, NP_067039, Q15919, Q9NQZ8, Q9UC09, Q9UQD3, ZNF71_HUMAN
UCSC ID: uc021vcg.1
Representative RNA: CCDS12947 Protein: Q9NQZ8 (aka ZNF71_HUMAN or ZN71_HUMAN)
CCDS: CCDS12947.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: CCDS12947.1
exon count: 1CDS single in 3' UTR: no RNA size: 1470
ORF size: 1470CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3040.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.