Human Gene MEGF9 (ENST00000373930.4) from GENCODE V44
Description: Homo sapiens multiple EGF like domains 9 (MEGF9), mRNA. (from RefSeq NM_001080497)
Gencode Transcript: ENST00000373930.4
Gencode Gene: ENSG00000106780.9
Transcript (Including UTRs)
Position: hg38 chr9:120,600,811-120,714,470 Size: 113,660 Total Exon Count: 6 Strand: -
Coding Region
Position: hg38 chr9:120,605,190-120,714,358 Size: 109,169 Coding Exon Count: 6
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: MEGF9_HUMAN
DESCRIPTION: RecName: Full=Multiple epidermal growth factor-like domains protein 9; Short=Multiple EGF-like domains protein 9; AltName: Full=Epidermal growth factor-like protein 5; Short=EGF-like protein 5; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).POLYMORPHISM: The poly-Ala stretch (positions 24 to 31) may be polymorphic and varies from 6 to 8 Ala residues.SIMILARITY: Contains 5 laminin EGF-like domains.CAUTION: It is uncertain whether Met-1 or Met-9 is the initiator.SEQUENCE CAUTION: Sequence=AAQ88736.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR013032 - EGF-like_CS
IPR002049 - EGF_laminin
IPR001368 - TNFR/NGFR_Cys_rich_reg
Pfam Domains: PF00053 - Laminin EGF domain
ModBase Predicted Comparative 3D Structure on Q9H1U4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AB011542 - Homo sapiens mRNA for MEGF9, partial cds.BC016989 - Homo sapiens multiple EGF-like-domains 9, mRNA (cDNA clone IMAGE:4396752), with apparent retained intron.AJ420444 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1622317.JD241516 - Sequence 222540 from Patent EP1572962.JD486556 - Sequence 467580 from Patent EP1572962.JD224401 - Sequence 205425 from Patent EP1572962.JD067358 - Sequence 48382 from Patent EP1572962.JD368334 - Sequence 349358 from Patent EP1572962.JD253594 - Sequence 234618 from Patent EP1572962.JD519974 - Sequence 500998 from Patent EP1572962.JD416845 - Sequence 397869 from Patent EP1572962.JD171741 - Sequence 152765 from Patent EP1572962.BC008313 - Homo sapiens multiple EGF-like-domains 9, mRNA (cDNA clone IMAGE:3050303).JD405534 - Sequence 386558 from Patent EP1572962.JD461460 - Sequence 442484 from Patent EP1572962.JD478145 - Sequence 459169 from Patent EP1572962.JD541989 - Sequence 523013 from Patent EP1572962.JD355625 - Sequence 336649 from Patent EP1572962.JD449830 - Sequence 430854 from Patent EP1572962.JD333099 - Sequence 314123 from Patent EP1572962.JD176197 - Sequence 157221 from Patent EP1572962.JD458021 - Sequence 439045 from Patent EP1572962.JD344501 - Sequence 325525 from Patent EP1572962.JD545651 - Sequence 526675 from Patent EP1572962.JD426930 - Sequence 407954 from Patent EP1572962.JD111889 - Sequence 92913 from Patent EP1572962.JD328600 - Sequence 309624 from Patent EP1572962.JD080078 - Sequence 61102 from Patent EP1572962.JD546150 - Sequence 527174 from Patent EP1572962.JD093013 - Sequence 74037 from Patent EP1572962.JD236232 - Sequence 217256 from Patent EP1572962.JD372967 - Sequence 353991 from Patent EP1572962.JD436478 - Sequence 417502 from Patent EP1572962.JD368738 - Sequence 349762 from Patent EP1572962.JD504094 - Sequence 485118 from Patent EP1572962.JD554314 - Sequence 535338 from Patent EP1572962.JD508350 - Sequence 489374 from Patent EP1572962.JD082956 - Sequence 63980 from Patent EP1572962.JD126344 - Sequence 107368 from Patent EP1572962.JD508461 - Sequence 489485 from Patent EP1572962.JD096134 - Sequence 77158 from Patent EP1572962.JD556720 - Sequence 537744 from Patent EP1572962.JD350453 - Sequence 331477 from Patent EP1572962.JD155294 - Sequence 136318 from Patent EP1572962.JD205536 - Sequence 186560 from Patent EP1572962.JD074765 - Sequence 55789 from Patent EP1572962.JD334049 - Sequence 315073 from Patent EP1572962.JD072978 - Sequence 54002 from Patent EP1572962.JD237191 - Sequence 218215 from Patent EP1572962.JD448994 - Sequence 430018 from Patent EP1572962.JD167249 - Sequence 148273 from Patent EP1572962.JD154828 - Sequence 135852 from Patent EP1572962.JD280293 - Sequence 261317 from Patent EP1572962.JD530537 - Sequence 511561 from Patent EP1572962.AK295380 - Homo sapiens cDNA FLJ54425 complete cds, highly similar to Multiple epidermal growth factor-like domains 9 precursor.JD444093 - Sequence 425117 from Patent EP1572962.JD069469 - Sequence 50493 from Patent EP1572962.BC156248 - Synthetic construct Homo sapiens clone IMAGE:100061692, MGC:190075 multiple EGF-like-domains 9 (MEGF9) mRNA, encodes complete protein.BC157029 - Synthetic construct Homo sapiens clone IMAGE:100063290, MGC:190731 multiple EGF-like-domains 9 (MEGF9) mRNA, encodes complete protein.JD088737 - Sequence 69761 from Patent EP1572962.JD370937 - Sequence 351961 from Patent EP1572962.JD492892 - Sequence 473916 from Patent EP1572962.JD249041 - Sequence 230065 from Patent EP1572962.JD263257 - Sequence 244281 from Patent EP1572962.JD370733 - Sequence 351757 from Patent EP1572962.JD044649 - Sequence 25673 from Patent EP1572962.JD434093 - Sequence 415117 from Patent EP1572962.JD308629 - Sequence 289653 from Patent EP1572962.JD063344 - Sequence 44368 from Patent EP1572962.JD543570 - Sequence 524594 from Patent EP1572962.DQ584459 - Homo sapiens piRNA piR-51571, complete sequence.AY358370 - Homo sapiens clone DNA64952 EGFL5 (UNQ671) mRNA, complete cds.JD384737 - Sequence 365761 from Patent EP1572962.JD389760 - Sequence 370784 from Patent EP1572962.JD211087 - Sequence 192111 from Patent EP1572962.JD157727 - Sequence 138751 from Patent EP1572962.JD460669 - Sequence 441693 from Patent EP1572962.JD059233 - Sequence 40257 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: B7Z315, EGFL5, ENST00000373930.1, ENST00000373930.2, ENST00000373930.3, KIAA0818, MEGF9_HUMAN, NM_001080497, O75098, Q9H1U4, uc022bms.1, uc022bms.2, uc022bms.3, UNQ671/PRO1305UCSC ID: ENST00000373930.4RefSeq Accession: NM_001080497
Protein: Q9H1U4
(aka MEGF9_HUMAN)
CCDS: CCDS48010.2
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.