Human Gene CDK5RAP3 (uc031rda.1) Description and Page Index
Description: Homo sapiens CDK5 regulatory subunit associated protein 3 (CDK5RAP3), transcript variant 1, mRNA. RefSeq Summary (NM_001278216): This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]. Transcript (Including UTRs) Position: hg19 chr17:46,048,322-46,059,152 Size: 10,831 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr17:46,053,257-46,058,868 Size: 5,612 Coding Exon Count: 7
ID:CK5P3_HUMAN DESCRIPTION: RecName: Full=CDK5 regulatory subunit-associated protein 3; AltName: Full=CDK5 activator-binding protein C53; AltName: Full=Protein HSF-27; FUNCTION: Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity). SUBUNIT: Interacts with CDK5R1. This interaction is prevented by the association between CDK5R1 and CDK5RAP3 (By similarity). Interacts with the enteric adenovirus serotype 41 fiber protein. Interacts with UFL1. INTERACTION: Q04206:RELA; NbExp=4; IntAct=EBI-718818, EBI-73886; TISSUE SPECIFICITY: Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta. PTM: Phosphorylated in vitro by CDK5 (By similarity). SIMILARITY: Belongs to the CDK5RAP3 family. SEQUENCE CAUTION: Sequence=AAK69655.1; Type=Frameshift; Positions=410;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05600 - Protein of unknown function (DUF773)
ModBase Predicted Comparative 3D Structure on Q96JB5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0001933 negative regulation of protein phosphorylation GO:0007095 mitotic G2 DNA damage checkpoint GO:0007420 brain development GO:0008283 cell proliferation GO:0010921 regulation of phosphatase activity GO:0030262 apoptotic nuclear changes GO:0030968 endoplasmic reticulum unfolded protein response GO:0031398 positive regulation of protein ubiquitination GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0043407 negative regulation of MAP kinase activity GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation GO:0044818 mitotic G2/M transition checkpoint GO:0045664 regulation of neuron differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0071569 protein ufmylation GO:0071901 negative regulation of protein serine/threonine kinase activity GO:1900182 positive regulation of protein localization to nucleus GO:1901798 positive regulation of signal transduction by p53 class mediator GO:1903363 negative regulation of cellular protein catabolic process GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process