Human Gene SLC35E2B (ENST00000617444.5) from GENCODE V44
  Description: Homo sapiens solute carrier family 35 member E2B (SLC35E2B), transcript variant 1, mRNA. (from RefSeq NM_001290264)
Gencode Transcript: ENST00000617444.5
Gencode Gene: ENSG00000189339.12
Transcript (Including UTRs)
   Position: hg38 chr1:1,661,478-1,692,795 Size: 31,318 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg38 chr1:1,665,782-1,676,699 Size: 10,918 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:1,661,478-1,692,795)mRNA (may differ from genome)Protein (405 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
LynxMGIneXtProtPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: S352B_HUMAN
DESCRIPTION: RecName: Full=Solute carrier family 35 member E2B;
FUNCTION: Putative transporter (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TPT transporter family. SLC35E subfamily.
SEQUENCE CAUTION: Sequence=BAA32292.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.88 RPKM in Pituitary
Total median expression: 583.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -445.70912-0.489 Picture PostScript Text
3' UTR -1675.704304-0.389 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000620 - DMT
IPR004853 - DUF250

Pfam Domains:
PF00892 - EamA-like transporter family
PF03151 - Triose-phosphate Transporter family

ModBase Predicted Comparative 3D Structure on P0CK96
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC110653 - Homo sapiens similar to solute carrier family 35, member E2, mRNA (cDNA clone MGC:117254 IMAGE:4392812), complete cds.
BC062371 - Homo sapiens solute carrier family 35, member E2, mRNA (cDNA clone IMAGE:3845538), partial cds.
BC010500 - Homo sapiens solute carrier family 35, member E2, mRNA (cDNA clone IMAGE:3449503).
BC073811 - Homo sapiens cDNA clone IMAGE:4842621, partial cds.
AL049249 - Homo sapiens mRNA; cDNA DKFZp564C093 (from clone DKFZp564C093).
CR936618 - Homo sapiens mRNA; cDNA DKFZp686M0869 (from clone DKFZp686M0869).
AB007916 - Homo sapiens KIAA0447 mRNA for KIAA0447 protein.
AK022944 - Homo sapiens cDNA FLJ12882 fis, clone NT2RP2003976, highly similar to Homo sapiens mRNA for KIAA0447 protein.
JD059026 - Sequence 40050 from Patent EP1572962.
JD042185 - Sequence 23209 from Patent EP1572962.
JD260800 - Sequence 241824 from Patent EP1572962.
JD419847 - Sequence 400871 from Patent EP1572962.
JD420691 - Sequence 401715 from Patent EP1572962.
JD299959 - Sequence 280983 from Patent EP1572962.
JD538219 - Sequence 519243 from Patent EP1572962.
JD251316 - Sequence 232340 from Patent EP1572962.
JD414122 - Sequence 395146 from Patent EP1572962.
JD152073 - Sequence 133097 from Patent EP1572962.
JD419004 - Sequence 400028 from Patent EP1572962.
JD357841 - Sequence 338865 from Patent EP1572962.
JD400398 - Sequence 381422 from Patent EP1572962.
JD424503 - Sequence 405527 from Patent EP1572962.
JD526420 - Sequence 507444 from Patent EP1572962.
JD146816 - Sequence 127840 from Patent EP1572962.
AK308064 - Homo sapiens cDNA, FLJ98012.
JD262606 - Sequence 243630 from Patent EP1572962.
JD400338 - Sequence 381362 from Patent EP1572962.
JD422808 - Sequence 403832 from Patent EP1572962.
JD353554 - Sequence 334578 from Patent EP1572962.
JD168715 - Sequence 149739 from Patent EP1572962.
JD233357 - Sequence 214381 from Patent EP1572962.
JD254261 - Sequence 235285 from Patent EP1572962.
JD416555 - Sequence 397579 from Patent EP1572962.
JD161290 - Sequence 142314 from Patent EP1572962.
JD273185 - Sequence 254209 from Patent EP1572962.
JD080060 - Sequence 61084 from Patent EP1572962.
JD271192 - Sequence 252216 from Patent EP1572962.
JD062598 - Sequence 43622 from Patent EP1572962.
JD496501 - Sequence 477525 from Patent EP1572962.
JD137161 - Sequence 118185 from Patent EP1572962.
JD115972 - Sequence 96996 from Patent EP1572962.
JD397665 - Sequence 378689 from Patent EP1572962.
JD086617 - Sequence 67641 from Patent EP1572962.
JD557643 - Sequence 538667 from Patent EP1572962.
JD206471 - Sequence 187495 from Patent EP1572962.
JD195805 - Sequence 176829 from Patent EP1572962.
JD366414 - Sequence 347438 from Patent EP1572962.
JD292560 - Sequence 273584 from Patent EP1572962.
JD557431 - Sequence 538455 from Patent EP1572962.
JD564084 - Sequence 545108 from Patent EP1572962.
JD093244 - Sequence 74268 from Patent EP1572962.
JD096241 - Sequence 77265 from Patent EP1572962.
JD408196 - Sequence 389220 from Patent EP1572962.
JD373291 - Sequence 354315 from Patent EP1572962.
JD421526 - Sequence 402550 from Patent EP1572962.
JD257045 - Sequence 238069 from Patent EP1572962.
JD514954 - Sequence 495978 from Patent EP1572962.
JD083931 - Sequence 64955 from Patent EP1572962.
JD238044 - Sequence 219068 from Patent EP1572962.
JD135690 - Sequence 116714 from Patent EP1572962.
JD135691 - Sequence 116715 from Patent EP1572962.
JD220261 - Sequence 201285 from Patent EP1572962.
JD223269 - Sequence 204293 from Patent EP1572962.
JD426594 - Sequence 407618 from Patent EP1572962.
JD379137 - Sequence 360161 from Patent EP1572962.
JD370197 - Sequence 351221 from Patent EP1572962.
JD351612 - Sequence 332636 from Patent EP1572962.
JD413309 - Sequence 394333 from Patent EP1572962.
JD198019 - Sequence 179043 from Patent EP1572962.
JD212641 - Sequence 193665 from Patent EP1572962.
JD246785 - Sequence 227809 from Patent EP1572962.
AK092311 - Homo sapiens cDNA FLJ34992 fis, clone OCBBF2011228, weakly similar to Mesembryanthemum crystallinum phosphoenolpyruvate/phosphate translocator precursor (PPT) mRNA.
AX747474 - Sequence 999 from Patent EP1308459.
JD146600 - Sequence 127624 from Patent EP1572962.
JD501999 - Sequence 483023 from Patent EP1572962.
JD412117 - Sequence 393141 from Patent EP1572962.
JD342373 - Sequence 323397 from Patent EP1572962.
JD532742 - Sequence 513766 from Patent EP1572962.
JD501238 - Sequence 482262 from Patent EP1572962.
JD480009 - Sequence 461033 from Patent EP1572962.
JD278391 - Sequence 259415 from Patent EP1572962.
JD425850 - Sequence 406874 from Patent EP1572962.
JD255716 - Sequence 236740 from Patent EP1572962.
JD212163 - Sequence 193187 from Patent EP1572962.
JD407453 - Sequence 388477 from Patent EP1572962.
JD070645 - Sequence 51669 from Patent EP1572962.
JD463269 - Sequence 444293 from Patent EP1572962.
JD535481 - Sequence 516505 from Patent EP1572962.
JD165296 - Sequence 146320 from Patent EP1572962.
JD262144 - Sequence 243168 from Patent EP1572962.
JD087137 - Sequence 68161 from Patent EP1572962.
JD367658 - Sequence 348682 from Patent EP1572962.
AK125619 - Homo sapiens cDNA FLJ43631 fis, clone SPLEN2031547.
JD302678 - Sequence 283702 from Patent EP1572962.
JD315895 - Sequence 296919 from Patent EP1572962.
JD554437 - Sequence 535461 from Patent EP1572962.
JD519702 - Sequence 500726 from Patent EP1572962.
JD093882 - Sequence 74906 from Patent EP1572962.
JD392853 - Sequence 373877 from Patent EP1572962.
JD546669 - Sequence 527693 from Patent EP1572962.
JD464154 - Sequence 445178 from Patent EP1572962.
JD396289 - Sequence 377313 from Patent EP1572962.
JD342614 - Sequence 323638 from Patent EP1572962.
JD549529 - Sequence 530553 from Patent EP1572962.
JD178577 - Sequence 159601 from Patent EP1572962.
JD461155 - Sequence 442179 from Patent EP1572962.
JD521141 - Sequence 502165 from Patent EP1572962.
JD027494 - Sequence 8518 from Patent EP1572962.
JD544556 - Sequence 525580 from Patent EP1572962.
JD031381 - Sequence 12405 from Patent EP1572962.
JD108147 - Sequence 89171 from Patent EP1572962.
JD283118 - Sequence 264142 from Patent EP1572962.
JD157472 - Sequence 138496 from Patent EP1572962.
JD235304 - Sequence 216328 from Patent EP1572962.
JD515775 - Sequence 496799 from Patent EP1572962.
JD102548 - Sequence 83572 from Patent EP1572962.
JD343840 - Sequence 324864 from Patent EP1572962.
JD066101 - Sequence 47125 from Patent EP1572962.
JD216802 - Sequence 197826 from Patent EP1572962.
JD316929 - Sequence 297953 from Patent EP1572962.
JD192876 - Sequence 173900 from Patent EP1572962.
JD533252 - Sequence 514276 from Patent EP1572962.
JD475829 - Sequence 456853 from Patent EP1572962.
JD081220 - Sequence 62244 from Patent EP1572962.
DQ596285 - Homo sapiens piRNA piR-34351, complete sequence.
JD192421 - Sequence 173445 from Patent EP1572962.
KJ900803 - Synthetic construct Homo sapiens clone ccsbBroadEn_10197 SLC35E2B gene, encodes complete protein.
AB384481 - Synthetic construct DNA, clone: pF1KA0447, Homo sapiens KIAA0447 gene for KIAA0447 protein, complete cds, without stop codon, in Flexi system.
AK307886 - Homo sapiens cDNA, FLJ97834.
BC092507 - Homo sapiens similar to solute carrier family 35, member E2, mRNA (cDNA clone IMAGE:4374954), with apparent retained intron.
JD383022 - Sequence 364046 from Patent EP1572962.
JD090174 - Sequence 71198 from Patent EP1572962.
JD498046 - Sequence 479070 from Patent EP1572962.
JD409551 - Sequence 390575 from Patent EP1572962.
JD058021 - Sequence 39045 from Patent EP1572962.
JD100866 - Sequence 81890 from Patent EP1572962.
JD247163 - Sequence 228187 from Patent EP1572962.
JD487040 - Sequence 468064 from Patent EP1572962.
JD210166 - Sequence 191190 from Patent EP1572962.
JD400167 - Sequence 381191 from Patent EP1572962.
JD565129 - Sequence 546153 from Patent EP1572962.
JD404100 - Sequence 385124 from Patent EP1572962.
JD178248 - Sequence 159272 from Patent EP1572962.
JD253454 - Sequence 234478 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KWR0, ENST00000617444.1, ENST00000617444.2, ENST00000617444.3, ENST00000617444.4, KIAA0447, NM_001290264, O75035, P0CK96, Q2TAY8, Q569F8, Q5CZA4, Q9Y3J8, S352B_HUMAN, uc031tmq.1, uc031tmq.2, uc031tmq.3
UCSC ID: ENST00000617444.5
RefSeq Accession: NM_001290264
Protein: P0CK96 (aka S352B_HUMAN)
CCDS: CCDS44041.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.