Human Gene DCDC2C (ENST00000399143.9) from GENCODE V44
  Description: Homo sapiens doublecortin domain containing 2C (DCDC2C), transcript variant 2, mRNA. (from RefSeq NM_001365580)
Gencode Transcript: ENST00000399143.9
Gencode Gene: ENSG00000214866.9
Transcript (Including UTRs)
   Position: hg38 chr2:3,703,575-3,848,008 Size: 144,434 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg38 chr2:3,703,752-3,847,183 Size: 143,432 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:3,703,575-3,848,008)mRNA (may differ from genome)Protein (364 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHGNC
LynxMGIneXtProtPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DCD2C_HUMAN
DESCRIPTION: RecName: Full=Doublecortin domain-containing protein 2C;
SIMILARITY: Contains 2 doublecortin domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.73 RPKM in Testis
Total median expression: 6.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -90.60177-0.512 Picture PostScript Text
3' UTR -213.20825-0.258 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003533 - Doublecortin_dom

Pfam Domains:
PF03607 - Doublecortin

ModBase Predicted Comparative 3D Structure on A8MYV0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0035556 intracellular signal transduction

Cellular Component:
GO:0005737 cytoplasm
GO:0005929 cilium
GO:0031514 motile cilium
GO:0036126 sperm flagellum
GO:0042995 cell projection


-  Descriptions from all associated GenBank mRNAs
 

-  Other Names for This Gene
  Alternate Gene Symbols: A8MYV0, DCD2C_HUMAN, ENST00000399143.1, ENST00000399143.2, ENST00000399143.3, ENST00000399143.4, ENST00000399143.5, ENST00000399143.6, ENST00000399143.7, ENST00000399143.8, NM_001365580, uc032nde.1, uc032nde.2, uc032nde.3, uc032nde.4
UCSC ID: ENST00000399143.9
RefSeq Accession: NM_001287444
Protein: A8MYV0 (aka DCD2C_HUMAN)
CCDS: CCDS74481.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.