Human Gene FGF16 (ENST00000439435.3) from GENCODE V44
Description: Homo sapiens fibroblast growth factor 16 (FGF16), mRNA. (from RefSeq NM_003868) RefSeq Summary (NM_003868): This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000439435.3 Gencode Gene: ENSG00000196468.8 Transcript (Including UTRs) Position: hg38 chrX:77,447,389-77,457,278 Size: 9,890 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chrX:77,447,675-77,456,522 Size: 8,848 Coding Exon Count: 3
ID:FGF16_HUMAN DESCRIPTION: RecName: Full=Fibroblast growth factor 16; Short=FGF-16; FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. SUBUNIT: Interacts with FGFR1 and FGFR2. SUBCELLULAR LOCATION: Secreted (By similarity). SIMILARITY: Belongs to the heparin-binding growth factors family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43320
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
