Human Gene SHC1 (ENST00000412170.5) from GENCODE V44
Description: SHC adaptor protein 1 (from HGNC SHC1) RefSeq Summary (NM_001202859): This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]. Gencode Transcript: ENST00000412170.5 Gencode Gene: ENSG00000160691.19 Transcript (Including UTRs) Position: hg38 chr1:154,967,670-154,974,336 Size: 6,667 Total Exon Count: 7 Strand: - Coding Region Position: hg38 chr1:154,967,670-154,970,196 Size: 2,527 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5T182
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.