Human Gene SHC1 (ENST00000412170.5) from GENCODE V44
  Description: SHC adaptor protein 1 (from HGNC SHC1)
RefSeq Summary (NM_001202859): This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
Gencode Transcript: ENST00000412170.5
Gencode Gene: ENSG00000160691.19
Transcript (Including UTRs)
   Position: hg38 chr1:154,967,670-154,974,336 Size: 6,667 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr1:154,967,670-154,970,196 Size: 2,527 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:154,967,670-154,974,336)mRNA (may differ from genome)Protein (200 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGencodeGeneCards
HGNCLynxMalacardsMGIPubMedUniProtKB
Wikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SHC1
Diseases sorted by gene-association score: astrocytoma (3), insulin-like growth factor i (2), breast cancer (2), epidermolysis bullosa, junctional, with pyloric stenosis (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 111.75 RPKM in Cells - Cultured fibroblasts
Total median expression: 1424.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.7092-0.312 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR006019 - PID_domain
IPR006020 - PTyr_interaction_dom

Pfam Domains:
PF00640 - Phosphotyrosine interaction domain (PTB/PID)

ModBase Predicted Comparative 3D Structure on Q5T182
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0030971 receptor tyrosine kinase binding

Biological Process:
GO:0001525 angiogenesis
GO:0007165 signal transduction
GO:0035556 intracellular signal transduction

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  BX647136 - Homo sapiens mRNA; cDNA DKFZp686J19171 (from clone DKFZp686J19171).
U73377 - Human p66shc (SHC) mRNA, complete cds.
BC033925 - Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1, mRNA (cDNA clone MGC:39145 IMAGE:4896385), complete cds.
BX647149 - Homo sapiens mRNA; cDNA DKFZp686L06171 (from clone DKFZp686L06171).
HV708928 - JP 2012506450-A/26: Methods for treating eye disorders.
HW061203 - JP 2012529430-A/78: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061205 - JP 2012529430-A/80: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JA482158 - Sequence 141 from Patent WO2011072091.
JA482160 - Sequence 143 from Patent WO2011072091.
JB252011 - Sequence 78 from Patent EP2440214.
JB252013 - Sequence 80 from Patent EP2440214.
JE980450 - Sequence 141 from Patent EP2862929.
JE980452 - Sequence 143 from Patent EP2862929.
LP764910 - Sequence 78 from Patent EP3276004.
LP764912 - Sequence 80 from Patent EP3276004.
X68148 - H.sapiens SHC mRNA.
BC014158 - Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1, mRNA (cDNA clone MGC:20839 IMAGE:4541216), complete cds.
HV708929 - JP 2012506450-A/27: Methods for treating eye disorders.
HW061204 - JP 2012529430-A/79: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
HW061206 - JP 2012529430-A/81: METHODS FOR TREATING CHRONIC KIDNEY DISEASE.
JA482159 - Sequence 142 from Patent WO2011072091.
JA482161 - Sequence 144 from Patent WO2011072091.
JB252012 - Sequence 79 from Patent EP2440214.
JB252014 - Sequence 81 from Patent EP2440214.
JE980451 - Sequence 142 from Patent EP2862929.
JE980453 - Sequence 144 from Patent EP2862929.
LP764911 - Sequence 79 from Patent EP3276004.
LP764913 - Sequence 81 from Patent EP3276004.
AB208849 - Homo sapiens mRNA for SHC (Src homology 2 domain containing) transforming protein 1 isoform p66Shc variant protein.
AK096169 - Homo sapiens cDNA FLJ38850 fis, clone MESAN2010031, highly similar to SHC TRANSFORMING PROTEIN.
BC011813 - Homo sapiens cDNA clone IMAGE:3161064, containing frame-shift errors.
BC017283 - Homo sapiens cDNA clone IMAGE:4890240, containing frame-shift errors.
AK296786 - Homo sapiens cDNA FLJ56101 complete cds, highly similar to SHC-transforming protein 1.
AK315842 - Homo sapiens cDNA, FLJ79491 complete cds, highly similar to SHC-transforming protein 1.
AK130014 - Homo sapiens cDNA FLJ26504 fis, clone KDN07054, highly similar to SHC transforming protein.
AK292143 - Homo sapiens cDNA FLJ75052 complete cds, highly similar to Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), transcript variant 2, mRNA.
AK225332 - Homo sapiens mRNA for SHC transforming protein 1 variant, clone: HEP09014.
HQ448284 - Synthetic construct Homo sapiens clone IMAGE:100071687; CCSB007372_03 SHC (Src homology 2 domain containing) transforming protein 1 (SHC1) gene, encodes complete protein.
KJ892137 - Synthetic construct Homo sapiens clone ccsbBroadEn_01531 SHC1 gene, encodes complete protein.
AB451255 - Homo sapiens SHC1 mRNA for SHC-transforming protein 1, complete cds, clone: FLJ08067AAAN.
AB451379 - Homo sapiens SHC1 mRNA for SHC-transforming protein 1, partial cds, clone: FLJ08067AAAF.
AB527815 - Synthetic construct DNA, clone: pF1KB9993, Homo sapiens SHC1 gene for SHC (Src homology 2 domain containing) transforming protein 1, without stop codon, in Flexi system.
CU680810 - Synthetic construct Homo sapiens gateway clone IMAGE:100017341 5' read SHC1 mRNA.
DL492542 - Novel nucleic acids.
DL491011 - Novel nucleic acids.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04012 - ErbB signaling pathway
hsa04062 - Chemokine signaling pathway
hsa04510 - Focal adhesion
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04722 - Neurotrophin signaling pathway
hsa04910 - Insulin signaling pathway
hsa05100 - Bacterial invasion of epithelial cells
hsa05214 - Glioma
hsa05220 - Chronic myeloid leukemia

BioCarta from NCI Cancer Genome Anatomy Project
h_epoPathway - EPO Signaling Pathway
h_il4Pathway - IL 4 signaling pathway
h_bcrPathway - BCR Signaling Pathway
h_ecmPathway - Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
h_igf1Pathway - IGF-1 Signaling Pathway
h_pdgfPathway - PDGF Signaling Pathway
h_vegfPathway - VEGF, Hypoxia, and Angiogenesis
h_TPOPathway - TPO Signaling Pathway
h_il2Pathway - IL 2 signaling pathway
h_p38mapkPathway - p38 MAPK Signaling Pathway
h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling
h_integrinPathway - Integrin Signaling Pathway
h_HBxPathway - Calcium Signaling by HBx of Hepatitis B virus
h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
h_ghPathway - Growth Hormone Signaling Pathway
h_il6Pathway - IL 6 signaling pathway
h_tffPathway - Trefoil Factors Initiate Mucosal Healing
h_egfPathway - EGF Signaling Pathway
h_erk5Pathway - Role of Erk5 in Neuronal Survival
h_mapkPathway - MAPKinase Signaling Pathway
h_pyk2Pathway - Links between Pyk2 and Map Kinases
h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells
h_il2rbPathway - IL-2 Receptor Beta Chain in T cell Activation
h_insulinPathway - Insulin Signaling Pathway
h_ngfPathway - Nerve growth factor pathway (NGF)
h_ptenPathway - PTEN dependent cell cycle arrest and apoptosis
h_tcrPathway - T Cell Receptor Signaling Pathway
h_trkaPathway - Trka Receptor Signaling Pathway
h_erkPathway - Erk1/Erk2 Mapk Signaling pathway
h_her2Pathway - Role of ERBB2 in Signal Transduction and Oncology
h_igf1rPathway - Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation
h_il3Pathway - IL 3 signaling pathway
h_longevityPathway - The IGF-1 Receptor and Longevity
h_spryPathway - Sprouty regulation of tyrosine kinase signals

-  Other Names for This Gene
  Alternate Gene Symbols: AK292143, ENST00000412170.1, ENST00000412170.2, ENST00000412170.3, ENST00000412170.4, Q5T182, Q5T182_HUMAN, RP11-307C12.1-008, uc057ljq.1
UCSC ID: ENST00000412170.5
RefSeq Accession: NM_001202859
Protein: Q5T182

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.