Human Gene KCNK1 (ENST00000446915.1) from GENCODE V44
  Description: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (from UniProt Q5T5E6)
RefSeq Summary (NM_002245): This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000446915.1
Gencode Gene: ENSG00000135750.15
Transcript (Including UTRs)
   Position: hg38 chr1:233,649,941-233,671,491 Size: 21,551 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr1:233,649,941-233,671,491 Size: 21,551 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:233,649,941-233,671,491)mRNA (may differ from genome)Protein (242 aa)
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-  Comments and Description Text from UniProtKB
  ID: Q5T5E6_HUMAN
DESCRIPTION: SubName: Full=Potassium channel subfamily K member 1; SubName: Full=Potassium channel, subfamily K, member 1; Flags: Fragment;
SIMILARITY: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: KCNK1
Diseases sorted by gene-association score: birk-barel mental retardation dysmorphism syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 59.02 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 330.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003280 - 2pore_dom_K_chnl
IPR005408 - 2pore_dom_K_chnl_TWIK
IPR001779 - 2pore_dom_K_chnl_TWIK1
IPR013099 - Ion_trans_2

Pfam Domains:
PF07885 - Ion channel

ModBase Predicted Comparative 3D Structure on Q5T5E6
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
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Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005267 potassium channel activity

Biological Process:
GO:0006811 ion transport
GO:0071805 potassium ion transmembrane transport

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  U90065 - Human potassium channel KCNO1 mRNA, complete cds.
U33632 - Human two P-domain K+ channel TWIK-1 mRNA, complete cds.
LP895736 - Sequence 600 from Patent EP3253886.
AK314016 - Homo sapiens cDNA, FLJ94673, highly similar to Homo sapiens potassium channel, subfamily K, member 1 (KCNK1), mRNA.
BC018051 - Homo sapiens potassium channel, subfamily K, member 1, mRNA (cDNA clone MGC:26384 IMAGE:4817185), complete cds.
U76996 - Homo sapiens two P domain potassium channel subunit (HOHO1) mRNA, complete cds.
CU676150 - Synthetic construct Homo sapiens gateway clone IMAGE:100018990 5' read KCNK1 mRNA.
DQ892383 - Synthetic construct clone IMAGE:100005013; FLH185798.01X; RZPDo839F02148D potassium channel, subfamily K, member 1 (KCNK1) gene, encodes complete protein.
DQ895595 - Synthetic construct Homo sapiens clone IMAGE:100010055; FLH185794.01L; RZPDo839F02147D potassium channel, subfamily K, member 1 (KCNK1) gene, encodes complete protein.
KJ897089 - Synthetic construct Homo sapiens clone ccsbBroadEn_06483 KCNK1 gene, encodes complete protein.
AK090902 - Homo sapiens cDNA FLJ33583 fis, clone BRAMY2011872, highly similar to Human two P-domain K+ channel TWIK-1 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: LP895736, Q5T5E6, Q5T5E6_HUMAN, RP4-550F15.1-006, uc057qll.1
UCSC ID: ENST00000446915.1
RefSeq Accession: NM_002245
Protein: Q5T5E6

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.