Human Gene CASP1 (ENST00000532439.6) from GENCODE V44
Description: Belongs to the peptidase C14A family. (from UniProt H0YEC7) RefSeq Summary (NM_033293): This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]. Gencode Transcript: ENST00000532439.6 Gencode Gene: ENSG00000137752.25 Transcript (Including UTRs) Position: hg38 chr11:105,025,443-105,031,175 Size: 5,733 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr11:105,025,553-105,031,175 Size: 5,623 Coding Exon Count: 6
ID:H0YEC7_HUMAN DESCRIPTION: SubName: Full=Caspase-1 subunit p20; Flags: Fragment; SIMILARITY: Belongs to the peptidase C14A family. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on H0YEC7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
